The development of High Speed Rail (HSR) in Europe has been encouraged and financially supported by the European Commission. Several lines are in operation, and many others under construction or waiting for approval. HSR technology is presented as a solution to congested roads and airports. Besides, rail transport is generally regarded as more environmentally friendly than other modes. However,...

Until recently, it was assumed that any short DNA segment could be regarded as a straight rod. Many instances, however, have been reported in which the helical axis was curved. In this study, to gain a general insight into the structural features of sequence-directed DNA curvatures, we constructed a set of plasmids carrying curved DNA segments, which were randomly cloned from Streptomyces total...

As a sustainable transportation mode, high-speed railway (HSR) has become an efficient way to meet the huge travel demand. However, due to the high acquisition and maintenance cost, it is impossible to build enough infrastructure and purchase enough train-sets. Great efforts are required to improve the transport capability of HSR. The utilization efficiency of train-sets (carrying tools of HSR)...

2566 Background: ABI is a cremophor-free formulation of paclitaxel which has been reported to have a lower incidence of HSRs. A retrospective evaluation was performed to determine the incidence of HSRs to ABI in pts with a history of HSRs to P. METHODS A query of the institutions medication database was performed to identify pts who received ABI during the evaluation period 2/05 - 5/09. A wai...

background: health system research (hsr) is system planning, coordination, monitoring and management of research resources and activities to achieve health and justice. as the main members of the health system, general practitioners (gps) play an important role in access to health care goals. the aim of the present study was to assess knowledge, attitude, and performance of gps in rafsanjan, ir...

The in-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, was tested against 51 clinical Neisseria gonorrhoeae isolates in comparison with ciprofloxacin, levofloxacin and sparfloxacin. The MICs of HSR-903 for 11 isolates with alterations in both GyrA and ParC, for 19 isolates with alterations only in GyrA and for 21 isolates without alterations in either GyrA or ParC ranged from 0....

Targeting the proteasome is a valuable approach for cancer therapy, potentially limited by pro-survival pathways that are induced in parallel to cell death. Whether these pro-survival pathways are activated in all cells, show different activation kinetics in sensitive versus resistant cells or interact functionally with cell death pathways is unknown. We monitored activation of the heat-shock r...

In the past it has been reproducibly demonstrated that 37 degrees C-grown DBY747 yeast cells have 29% more unsaturated fatty acids and a 3 degrees C higher maximal heat shock response (HSR) than their 25 degrees C counterparts. Suddenly the HSR and lipid profiles of cells grown at 25 degrees C and 37 degrees C became indistinguishable from one another. This paper reports an aberrantly high leve...