Histocompatibility in transplantation is governed by the products of the human leucocyte antigen (HLA) genes encoded within the major histocompatibility complex (MHC) on chromosome 6p21. HLA antigens define tissue type and are inherited en bloc in classical Mendelian fashion. Genotypically identical siblings inherit the same paternal and maternal chromosome 6. Haploidentical relatives share one...

Malignancy is the second most common cause of mortality in the reproductive period and it complicates up to one out of every 1000 pregnancies. When cancer is diagnosed during pregnancy, the management approach must take into consideration both the mother and her fetus. Hematologic cancers diagnosed in pregnancy are not common, resulting in paucity of randomized controlled trials. Diagnosis of s...

T HE ARTICLE BY Gisselbrecht et all in this issue of Blood describes the activity of single-agent interleukin-2 (IL-2) in a heterogeneous group of previously treated patients with malignant non-Hodgkin’s lymphoma (NHL), Hodgkin’s disease, and cutaneous T-cell lymphoma (CTCL). The number of patients within each of the defined groups is relatively small, and the confidence intervals surrounding t...