BACKGROUND The highly orchestrated process of blood cell development and homeostasis is termed "hematopoiesis." Understanding the biology of hematopoietic stem cells as well as hematopoiesis is important to developing improved treatments for hematologic malignancies, congenital disorders, chemotherapy-related cytopenias, and blood and marrow transplants. METHODS The author reviews the current...

Autologous hematopoietic stem cell transplantation has proved to be an effective treatment for certain hematologic malignancies. However, relapse rates are high during the first year after transplantation. These relapses are attributed to the failure of high-dose chemotherapy to eradicate minimal residual malignant disease. In allogeneic hematopoietic stem cell transplantation, the higher antit...

High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation has been explored as a method to enhance the efficacy of chemotherapy for advanced solid tumors. The failure of autologous hematopoietic stem cell transplantation to prolong survival in patients with metastatic solid tumors has sparked interest recently in studies exploring the potential of allogeneic hematopo...

Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In this review, we summarize current aspects ...

The purpose of regenerative medicine [6], especially tissue engineering, is to replace damaged tissue with new tissue that will allow the body to resume normal function. The uniqueness of tissue engineering is that it can restore normal structure in addition to repairing tissue function, and is often accomplished using stem cells [7]. The first type of tissue engineering using stem cells [7] wa...

s and Treatment Recommendations Abstract: Stem Cell Transplantation in the Therapy of ALL in Children [1] Evidence supporting the role of hematopoietic stem cell transplantation (SCT) in the therapy of acute Table 1. Grading the Quality of Design and Strength of Evidence Stem Cell Transplantation in the Therapy of ALL in Children [1] Evidence supporting the role of hematopoietic stem cell trans...

background: it is still controversial that the stem cells isolated from human dental pulp meets the criteria for mesenchymal stem cells (mscs). the aim of the present study was to examine whether or not they are mscs, or are distinct stem cells population residing in tooth pulp.   methods: adherent fibroblastic cells in the culture of pulp tissue from human third molars were propagated through ...

Hematopoietic stem cell transplantation(HSCT), has been accepted as a feasible treatment option that prolongs survival in hematological malignancies. Stem cell choice during hematopoietic stem cell transplantation can differ according to the experience of physicians, mostly treated hematological diseases in the centers or ongoing clinical trials. In this chapter we will discuss the advantages a...

The concept and characteristics of different types of hematopoietic cells have been described. Hematopoietic stem cells are currently considered to exist in a variety of populations with different degrees of commitment towards a particular cell line. By a combination of animal studies and studies with hematopoietic disorders, the concept of dividing hematopoietic stem cells into uncommitted and...