objective: to investigate the decrease in hemoglobin concentration and hematocrit during elective surgery. methods: this was a prospective study being performed in nemazee hospital of shiraz university of medical sciences. we included a total of 50 american society of anesthesiology (asa) i and ii patients undergoing elective minor surgeries. perioperative fluid administration was performed for...

background: &beta-thalassemia; is the most common monogenic disorder in human. the (ct) polymorphism at -158 upstream region of the &gammag-globin; gene and pharmacological factors such as hydroxyurea have been reported to influence &gamma-globin; gene expression and the severity of clinical symptoms of &beta-thalassemia.; methods: in the present study, 51 &beta-thalassemia; intermediate patie...

introduction: hemoglobin a1c (hba1c) reflects patient’s glycemic status over the previous 3 months. previous studies have reported that iron deficiency may elevate a1c concentrations, independent of glycemia. this study is aimed to analyze the effect of iron deficiency anemia on hba1c levels in diabetic population having plasma glucose levels in control. methods: totally, 120 diabetic, iron-def...

potent induction of fetal hemoglobin (hbf) production results in alleviating the complications of β-thalassemia and sickle cell disease (scd). hbf inducer agents can trigger several molecular signaling pathways critical for erythropoiesis. janus kinase/signal transducer and activator of transcription (jak/stat), mitogen activated protein kinas (mapk) and phosphoinositide 3-kinase (pi3k) are con...

our previous studies on thalassemia patients, homozygous or compound heterozygous for severe beta thalassemia mutations, has suggested that 5’hs4-lcr and/or xmn1-hbg2 backgrounds, which were linked in our thalassemia patients, are important in determining the blood transfusion dependency of these individuals. while the majority of patients with aa/-- 5’hs4/xmn1 background, were severely depende...

conclusions according to the results of this study, this increase could be due to higher fuel consumption, usage of gasoline in vehicles, oil industry, and steel and heavy industries in ahwaz. the risk of mortality and morbidity were detected at the current concentrations of air pollutants. results according to the findings, the concentration of sulfur dioxide in ahvaz had an annual average of ...

The hemodynamic effects of a 20% exchange-transfusion with different solutions of highly purified human hemoglobin A-zero (A0) were evaluated. We compared unmodified hemoglobin with hemoglobin cross-linked with O-raffinose. Unmodified hemoglobin increased systemic vascular resistance and mean arterial pressure more than the O-raffinose cross-linked hemoglobin solution (by approximately 45% and ...

This paper discusses a current misinterpretation between different parameters of hemoglobin concentration measurement and its amplification under conditions of blood loss. The paper details the distinction between microcirculatory hematocrit and the hematocrit of the macrocirculation to analyze clinical use of real-time patient hemoglobin concentration measurement by noninvasive point-of-care d...