BACKGROUND In vitro hemolysis can be induced by several biological and technical sources, and may be worsened by forced aspiration of blood in vacuum tubes. This study was aimed to compare the probability of hemolysis by drawing blood with a commercial evacuated blood collection tube, and S-Monovette used either in the "vacuum" or "aspiration" mode. MATERIALS AND METHODS The study population ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare chronic hemolytic anemia characterized by an acquired defect of the erythrocyte which renders it susceptible to hemolysis by normal human serum. Previous reports have indicated that magnesium and factors resembling the components of complement are required for the hemolysis in vitro of PNH erythrocytes by normal serum (1, 2). Recently a natura...

background: copper sulfate ingestion is a relatively popular method for committing suicide in indian subcontinent. it causes a high mortality rate, and so a growing concern has been raised to identify the severe alarming signs suggestive of poor prognosis and to improve treatment approaches. case report: a 22-year-old unmarried man working as a painter was found unconscious at his friend reside...

Transcatheter closure of a patent ductus arteriosus (PDA) is an established technique that may rarely be complicated by severe intravascular hemolysis due to residual shunt. Although conservative management has been reported, the usual approach is to invasively eliminate the residual shunt. We report a case where misjudgment of PDA size and subsequent attempted closure with only one coil led to...

An 80-year-old female was admitted to our hospital due to malaise. The initial diagnosis on admission was pernicious anemia (PA), Hashimoto thyroiditis and autoimmune atrophic gastritis. Autoimmune hemolytic anemia was suspected because direct antiglobulin test (DAT) was positive. Treatment with vitamin B12 improved anemia, with the disappearance of hemolysis. In some cases, PA patients with po...

Case Summary A 47 year-old African American man presented to the hospital with three a day history of fever, shortness of breath, nausea, emesis, dark urine, and progressive confusion. The symptoms began one day following an infusion of a “vitamin complex” at his physician’s office. The patient’s medical history was significant for retroperitoneal fibrosis with multiple urological procedures, f...

The propensity of certain chemicals and drugs to induce hemolytic anemias has been a subject of much interest for almost a century (1-4). The majority of substances so active are aromatic compounds containing amino-, nitro-, or hydroxy groups, although a number of inorganic compounds (e.g., hydroxylamines, nitrates, nitrites and chlorates) are also active (1-4). Such compounds usually cause red...