objective(s):the current study was aimed to determine the bioactive constituents and biological effects of the crataegus monogyna ethanolic extracts from bark, leaves and berries on hypercholesterolemia. materials and methods: oleanolic acid, ursolic acid, quercetin and lupeol concentrations were quantified by hplc. total phenol content and radical scavenging activity of extracts were also meas...

objective(s): particularly in developing countries, selenium and/or iodine deficiencies are encountered and use of pesticides in agriculture are not well-controlled. fenvalerate is a pyrethroid insectide used in agriculture and has applications against a wide range of pests. this study was designed to evaluate the effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzyme act...

diabetes is one of the most common metabolic disorders and is interrelated to oxidative stress-induced diseases. according to the role of dietary antioxidants in control and prevention of diabetes, this study was aimed to evaluate the effect of green tea extract on serum glucose levels and serum and hepatic total antioxidant capacity (tac) and lipid (mda) in diabetic rats. experimental diabetes...

context patients with hepatic dysfunction suffer from many problems and associated complications in organs other than the liver. therefore, it is very important to investigate the effects of different drugs in the treatment of these patients. due to the high consumption of non-steroidal anti-inflammatory drugs (nsaids), studying the effects of these drugs in patients with hepatic dysfunction is...

background and objectives this study was undertaken to evaluate the effect of the cultivated satureja khuzestanica essential oil (skeo) on activity and gene expression of hepatic gk in normal and diabetic rats.   methods biochemical parameters such as glucose, insulin, and hba1c plasma levels and oral glucose tolerance test were all analyzed. the cultivated skeo was orally administered at diffe...

OBJECTIVE Hepatic steatosis is common in type 2 diabetes. It is causally linked to the features of the metabolic syndrome, liver cirrhosis, and cardiovascular disease. Experimental data have indicated that increased liver fat may impair hepatic perfusion and metabolism. The aim of the current study was to assess hepatic parenchymal perfusion, together with glucose and fatty acid metabolism, in ...

Since in the usual perfusion of isolated rat liver via the portal vein an insulin-dependent increase of hepatic glucose uptake could not be demonstrated, the possibility was considered that hepatic glucose uptake might not be a function of the absolute concentration of this substrate but of its concentration gradient between the portal vein and the hepatic artery. Therefore a new method was est...