The hepatic bile acid transporter NTCP is a high-affinity receptor for hepatitis B and D viruses. This study shows that TLC rapidly accumulates in NTCP-expressing hepatoma cells mediates long-lasting trans-inhibition of NTCP’s function via an intracellularly accessible domain, without substantially affecting its membrane expression. domain promising novel target site pharmacological long-acting...

BACKGROUND HIV-1 and Hepatitis B and C viruses coinfection is common in Sub-Saharan Africa due to similar routes of transmission and high levels of poverty. Most studies on HIV-1 and Hepatitis B and C viruses have occurred in hospital settings and blood transfusion units. Data on Hepatitis B and C viruses and HIV-1 coinfection in informal urban settlements in Kenya are scanty, yet they could pa...

HIV and hepatitis B virus (HBV) coinfection increases HIV and HBV replication, hepatitis flares, and risk of progression to chronic HBV infection, cirrhosis, and hepatocellular carcinoma. HIV and HBV coinfection decreases frequency of hepatitis Be antibody (anti-HBe) and hepatitis B surface antibody (anti-HBs) seroconversion, increases risk of antiretroviral therapy-related hepatotoxicity, and ...

Lymphoma is a common hematological malignancy. Hepatitis viruses, especially hepatitis B and hepatitis C, are known risk factors for development of non-Hodgkin lymphomas. However, there are a number of patients with hepatitis in whom no virus can be identified and it was therefore postulated that there may be other agents which may be causing hepatitis. Many new hepatitis viruses have indeed be...

INTRODUCTION The epidemiology of viral hepatitis during pregnancy is of paramount importance for health planners and program managers. Data on viral hepatitis during pregnancy are not readily available in many African and Arab countries. Both regions have their own unique geography, and comprise over 59 states with crossover and interaction of different cultures. METHODOLOGY A systematic elec...

INTRODUCTION The history of viral hepatitis goes back thousands of years and is a fascinating one. When humans were first infected by such agents, a natural repetitive cycle began, with the capacity to infect billions of humans, thus decimating the population and causing sequelae in thousands of lives. METHODS This article reviews the available scientific information on the history of viral h...

OBJECTIVE Several infectious diseases are transmissible by blood transfusion, especially viral infections. The most common blood-transmitted viruses are hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). These viruses cause fatal, chronic and life-threatening disorders. The prevalence of these viruses varies by nationality and geography. The purpose of this...

Common Hepatitis A and B viruses Rare Hepatitis C and D (6) viruses, Epstein-Barr virus, Cytomegalovirus Among a subpopulation ofhomosexual men the risk ofinfection with the human immunodeficiency virus (HIV) has brought about a change in sexual behaviour with a reduction in the number of partners and "safer" sexual practices. This has resulted in a reduced incidence ofcommon sexually transmitt...

Myocarditis, until lately out of favour, is again becoming an acceptable diagnosis. The myocardium can be attacked by many organisms such as bacteria, viruses, fungi, rickettsiae, spirochaetes, and parasites. Viruses are of special importance, and acute or chronic myocarditis has been occasionally described in such viral infections as measles, mumps, poliomyelitis, infectious mononucleosis, psi...

We wish to share our experience on the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients with chronic liver disease (CLD) during two year study period. Both of these viruses are transmitted mainly through the parenteral route and therefore a dual infection of these viruses occurs and even persists in the same patient. Seroprevalence studies have also shown coinfectio...