In the present study, various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy LC-MS spectrometry, besides elemental analysis. The compounds evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small lung cancer), MCF-7 (breast HT-29 (colorectal adenocarcinoma PC-3 (andro...

Hepatocellular carcinoma is highly chemoresistant, and ATP-binding cassette subfamily G member 2 (ABCG2) is thought to play a critical role in this drug resistance. The present study aims to develop effective therapeutic strategies to decrease ABCG2 expression level and to surmount drug resistance in hepatocellular carcinoma chemotherapy. First, we verified a positive correlation between the AB...

Various epidemiologic studies have shown that obesity is associated with hepatocellular carcinoma. Leptin, the key player in the regulation of energy balance and body weight control, also acts as a growth factor on certain organs in both normal and disease states. It is plausible that leptin acts to promote hepatocellular carcinogenesis directly affecting malignant properties of liver cancer ce...

BACKGROUND Liver cancer is the second leading cause of cancer death in men worldwide. Hepatocellular carcinoma usually develops in the setting of cirrhosis or chronic inflammation. Major risk factors for developing hepatocellular carcinoma are chronic hepatitis B or C virus infection, alcoholic cirrhosis, and nonalcoholic fatty liver disease. The most frequent locations for hepatocellular carci...

Mutation in several factors and pathways leads to the development of hepatic cancer i.e. Wnt-β-Catenin Signalling Pathway , activation Insulin-Like Growth Factor (IGF) Pathway, The P13/PTEN/AKT, TP53 Tumour Suppressor Gene. Liver cirrhosis fatty liver predispose normal tissues fibrosis leading cancer. Excessive alcohol intake results inflammation proceeding ultimately carcinoma. Hepatocellular ...

Altered glycosylation is a hallmark of cancer. The core 1 b1,3-galactosyltransferase (C1GALT1) controls the formation of mucin-type O-glycans, far overlooked and underestimated in cancer. Here, we report that C1GALT1 mRNA and protein are frequently overexpressed in hepatocellular carcinoma tumors compared with nontumor liver tissues, where it correlates with advanced tumor stage, metastasis, an...

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of leading causes cancer-related deaths worldwide. The multitarget inhibitor sorafenib a first-line treatment patients with advanced unresectable HCC. Recent clinical studies have evidenced that treated together antidiabetic drug metformin survival disadvantage compared receiving only. Here, we examined whether c...