Table S1 : Human gene sets retrieved from published experiments and used to determine gene sets detected in HepG2 cells (Full), liver (set 1) or deregulated in hepatocellular carcinoma HCC (set2). 20839 4918 806 Full Liver (set 1) HCC (set 2)

BACKGROUND Spleen-deficiency syndrome (SDS) in Traditional Chinese Medicine (TCM) played pivotal roles on the development of hepatocellular carcinoma (HCC). This study was performed to establish and evaluate HCC model in mice with SDS in TCM. MATERIAL AND METHODS A total of 90 C57BL/6 mice were randomized in six groups (n=15 for each group): A, Control group; B, SDS group; C, orthotopic HCC (...

CONTEXT Alpha-1-antitrypsin (A1AT) is the most abundant liver-derived, highly polymorphic, glycoprotein in plasma. Hereditary deficiency of alpha-1-antitrypsin in plasma (A1ATD) is a consequence of accumulation of polymers of A1AT mutants in endoplasmic reticulum of hepatocytes and other A1AT-producing cells. One of the clinical manifestations of A1ATD is liver disease in childhood and cirrhosi...

Abstract: Background and Aim: To study the antitumor activity of 2-Methoxy-1,4-naphthoquinone (MNQ) against hepatocellular carcinoma (HCC) cells, in an attempt to fill knowledge gap anti-liver cancer with MNQ. Materials Methods: Cell viability presence MNQ was assessed by MTT effect on HepG2 cell cycle flow cytometry. analyze apoptosis its molecular mechanisms, we used a combination Hoechst 333...

Hepatocellular carcinoma (HCC) is considered the leading cause of primary liver malignancy, however, a tumor arising from biliary tree should be always kept among differential diagnosis. Cholangiocarcinoma (CCA) group malignancies that represents 10-20% all masses being perihilar cholangiocarcinoma most common and intrahepatic less subtype. Important biomarkers such as serum alpha-fetoprotein (...

Liver surgery is the first-line treatment for hepatocellular carcinoma (HCC). Minimally invasive liver resection (MILS) has become an attractive option thanks to reduced intraoperative blood losses, shortened length of hospital stay, and similar oncological outcomes when compared open resection. Nonetheless, safety MILS still debated in challenging situations, such as cirrhotic patients, diffic...

BACKGROUND The impact of pre-existing diabetes mellitus (DM) on hepatocellular carcinoma (HCC) occurrence and prognosis is complex and unclear. The aim of this meta-analysis is to evaluate the association between pre-existing diabetes mellitus and hepatocellular carcinoma occurrence and prognosis. METHODS We searched PubMed, Embase and the Cochrane Library from their inception to January, 201...

Hepatocellular carcinoma (HCC) is the most common primary tumour of the liver. Cholangiohepatocellular carcinoma (CHC) is less common and is a variant of HCC. There are many similarities with HCC with the exception that CHC tend to be more aggressive. We report a case of a 50-year-old man who was diagnosed with CHC and suddenly deteriorated secondary to hepatic tumour rupture. Despite aggressiv...

Abstract Background Interleukin-4 (IL-4), a pleiotropic anti-inflammatory cytokine, is produced mainly by activated T helper 2 (Th2). Hepatocellular carcinoma (HCC) typical inflammation-related cancer. Alterations influencing IL-4 expression may disturb immune response and be associated with HCC risk. We aimed to verify role of IL4 gene polymorphism ( IL-4-589C/T (rs2243250 )) in HCV-related he...

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of leading causes cancer-related deaths worldwide. The multitarget inhibitor sorafenib a first-line treatment patients with advanced unresectable HCC. Recent clinical studies have evidenced that treated together antidiabetic drug metformin survival disadvantage compared receiving only. Here, we examined whether c...