BACKGROUND Approximately one third of the hereditary diffuse gastric cancer (HDGC) families carry germline mutations in the E-cadherin gene (CDH1). Risk prediction in members of families with this rare but deadly cancer could be improved by the identification of additional HDGC genes in non-CDH1 families. METHODS Affected individuals from 22 CDH1 mutation-negative families were screened for g...

BACKGROUND Better understanding about gastric cancer incidence patterns among Hispanics by birthplace, socioeconomic status (SES), and acculturation can improve preventive strategies and disease models. METHODS Incidence rates, rate ratios, and estimated annual percent change (EAPC) in rates of anatomic and histologic subtype-specific gastric cancer were calculated by age, sex, and nativity a...

various substances in cigarette smoke including nicotine have been shown to promote/induce cancer cell proliferation. since cotinine has a longer half life and stability in the blood, it has become the preferred biomarker for cigarette smoking exposure. seventy-three gastric cancer patients were included in this study. the tumor tissues were stained with h and e for pathological evaluation. the...

Laurèn's system subdivides gastric cancers into an intestinal type and a diffuse type. This histological classification mirrors histogenetic hypotheses according to which the intestinal-type cancer derives from intestinal metaplasia and dysplasia, while the diffuse-type originates directly from gastric mucosa, with or without a preceding non-metaplastic dysplasia. Studies concerning mucins expr...

IQGAP1 is recognized as a negative regulator of cell-cell adhesion at adherens junctions in several cell types, including gastric mucosal cells. The histopathologic appearance of diffuse gastric carcinoma is defined by non- or poorly cohesive tumor cells, indicating abnormal intercellular adhesion. Hence, we screened 38 gastric cancers for activating point mutations in IQGAP1. In 2 of the 33 di...

The gastric cancer risk varies based on the etiology and severity of gastritis, which depends a history Helicobacter pylori infection secretory capacity stomach. Type A gastritis is associated with reverse atrophy corpus type B progressive extending from antrum to corpus. Diffuse or spotty redness in together high serum pepsinogen (PG) II levels low PG I/II ratio are observed patients H. when s...