DIEM: drug-induced erythema multiforme EM: erythema multiforme HAEM: herpes-associated erythema multiforme HSV: herpes simplex virus PCR: polymerase chain reaction INTRODUCTION Adalimumab is a recombinant human IgG1 monoclonal antibody specific for human tumor necrosis factor. We report a case of recurrent erythema multiforme (EM) recalcitrant to previous therapy that showed complete response t...

The antiherpesvirus agent penciclovir (PCV) shares an identical activation pathway and a similar mode of action with acyclovir (ACV). However, since PCV represents a relatively recent treatment option, the clinical resistance profile to PCV is less well known. A susceptibility program was established to assess the resistance profile for serial herpes simplex virus isolates from immunocompetent ...

Dental and dental hygiene students frequently interact with patients with herpes simplex virus (HSV) infections, often simply referred to as cold sores. The objectives of this study were to assess dental and dental hygiene students' knowledge, attitudes, and professional behavior concerning the treatment of patients with HSV infections and to investigate the relationships among knowledge, attit...

INTRODUCTION Worldwide, about 90% of people are infected with the herpes simplex virus, 30% of whom will experience recurrent herpes simplex labialis, commonly referred to as 'cold sores', which can last up to 10 days. The most common treatment is aciclovir cream which reduces healing time by just half a day compared with no specific treatment. This is a protocol for a randomised controlled tri...

A leading sexually transmitted disease, the herpes virus, infects more than two-thirds of all people. An evolutionary question for scientists has been why humans are the only primate species that harbor two forms of the herpes simplex virus (HSV): HSV-1 (causing cold sores) and HSV-2 (genital herpes). Wertheim et al. (2014) used a novel model of molecular evolution to demonstrate that HSV-1 lik...

Experimental studies in chickens have shown a relationship of a herpesvirus to atherosclerosis. The hypothesis of an association in humans was tested by using data on the history of cold sores and other manifestations of herpes infections reported by 658 male and 919 female participants (ages 58 to 89) in the Framingham Heart Study from 1977 to 1979 and on the prevalence and subsequent 6-year i...

Herpes simplex (or just “Herpes”) is another name for the “cold sore” virus. It commonly causes local blisters and scabbing around the mouth and nose but occasionally infects the eye where, unlike the skin, it may cause scarring or chronic inflammation. The cold sore virus is a different strain of herpes than the one associated with sexually transmitted disease; ocular herpes is not an STD. Col...

BACKGROUND The Internet has tremendous appeal for conducting randomized clinical trials and may be especially applicable to trials requiring frequent participant contact. Trials of cold sore remedies, for example, often require daily clinic visits during outbreaks, imposing substantial burden on participants. An Internet-based randomized clinical trial design may reduce this burden, permitting ...