نتایج جستجو برای: high affinity receptor
تعداد نتایج: 2600326 فیلتر نتایج به سال:
aptamers define a new interesting class of receptor molecules with capability of binding to potentially any kind of molecules of interest. structurally, they are composed of nucleic acids (rna, dna or a mixture of both) with high specificity and affinity to amino acids, drugs, proteins and other molecules. apatmers are isolated from complex libraries of synthetic nucleic acids against the desir...
In this study, we investigated the relationship between affinity to somatostatin receptor subtype2 (SSTR(2)) and uptake of radioactivity from a group of radiolabeled somatostatin analogues in somatostatin receptor-rich tissues of rats. Organs with a high density of somatostin receptors (namely the adrenals and pancreas bearing mainly SSTR(2); this receptor subtype is also the most abundant in s...
IgG FcRs are important mediators of immunity and play a key role during Ab-based immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable of IgG binding with high affinity. FcγRI exists as a complex of a ligand binding α-chain and an FcR γ-chain. The receptors' α-chain can, furthermore, elicit several functions independent of the ITAM-bearing FcR γ-chain. Functional implic...
The vanilloid receptor VR1 is a polymodal nociceptor sensitive to capsaicin, protons, and heat. Because VR1 represents an attractive therapeutic target for conditions ranging from long-term pain to bladder hyperreflexia, we and other groups have sought to develop novel ligands with enhanced potencies and novel pharmacological properties. Here, we characterize two compounds, N-[2-(3,4-dimethylbe...
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