conclusions our findings indicate that heterogeneity at +2109 locus of ifn-γ gene but not at +874 locus could interfere with successful therapy in patients infected with hcv genotype 1. results of 158 patients, 110 (69.5%) subjects achieved svr and 48 (30.5%) subjects did not respond to therapy. the frequency of aa genotype (p = 0.001; or: 11.2; ci: 2.26-63.21) and a allele (p = 0.01; or: 3.23;...

Semliki Forest virus vectors expressing IL-12 (SFV-IL-12) were shown to induce potent antitumor responses against s.c. MC38 colon adenocarcinomas in immunocompetent mice. However, when MC38 tumors were implanted in liver, where colon tumors usually metastasize, SFV-IL-12 efficacy was significantly reduced. We reasoned that characterization of immune responses against intrahepatic tumors in resp...

Imatinib mesylate is a first line treatment of Chronic Myelogenous Leukemia and of a rare form of gastrointestinal stromal cancer, where the response to the drug is also linked to the immune system activation with production of antineoplastic cytokines. In this study, forty patients in the chronic phase of disease, treated with imatinib mesylate, were analyzed. Bone marrow aspirates were drawn ...

Secondary Tc cells generated against Sindbis virus (SIN) are restricted to Dk. All other H-2K or D regions tested show low specific responsiveness. F1 hybrids between low and high responders show dominance of responsiveness but lack complementation. When BALB/c (KdIdDd) low responder fetal liver stem cells were allowed to mature in irradiated high responder recipients C3H.OH (KdIdDk) a response...

Psychological stress has been reported to be related to higher blood pressure (BP) and unfavorable cardiovascular profile. However, because of the complexity of personal stress management, a multilevel stress measurement strategy is needed. The aim of this cross-sectional study was to analyze the respective influences of the subjective perception of professional strain (high demand and low lati...

The article studies deliberation aspects by modelling a responder in multi-proposers ultimatum game (UG). Compared to the classical UG, deliberative multi-proposers UG suggests that at each round the responder selects the proposer to play with. Any change of the proposer (compared to the previous round) is penalised. The simulation results show that though switching of proposers incurred non-ne...

Introdoction: Hepatitis B comprises one of the major health problems worldwide. Health Care Workers (HCW) are a group at risk for Hepatitis B Virus (HBV) infection. The aim of this study is Management of nonresponder health care workers to hepatitis B routine vaccination. Methods: In a descriptive-analytical study conducted in the Department of infectious diseases in the University Of Medical S...

Between June, 1984 and January 20, 1987, 69 kidney transplantations were performed in our department. All kidneys were acquired from living donors. 63% of the cases were high-risk MLC-positive (poorly matched), and all but one were from related sources. There were only five rejected kidneys, all of which occurred in kidneys from parent donors. 28 recipients received donor-specific transfus...