This paper discusses design methodology of high-throughput arithmetic pipeline modules for an FPGA-based biochemical simulator. Since limitation of data-input bandwidth caused by port constraints often has a negative impact on pipeline scheduling results, we propose a priority assignment method of input data which enables efficient arithmetic pipeline scheduling under given input port constrain...

A reordered overlapped search mechanism for high-throughput low-energy contentaddressable memories (CAMs). Most mismatches can be found by searching a few bits of a search word. To lower power dissipation, a word circuit is often divided into two sections that are sequentially searched or even pipelined. Because of this process, most of match lines in the second section are unused. Since search...

With the development of ultra-high-throughput technologies, the cost of sequencing bacterial genomes has been vastly reduced. As more genomes are sequenced, less time can be spent manually annotating those genomes, resulting in an increased reliance on automatic annotation pipelines. However, automatic pipelines can produce inaccurate genome annotation and their results often require manual cur...

MOTIVATION Over the past decade, the prospect of inferring networks of gene regulation from high-throughput experimental data has received a great deal of attention. In contrast to the massive effort that has gone into automated deconvolution of biological networks, relatively little effort has been invested in benchmarking the proposed algorithms. The rate at which new network inference method...

Certain sciences such as physics, chemistry or biology, have a strong computational aspect and use computing infrastructures to advance their scientific goals. Often, high performance and/or high throughput computing infrastructures such as clusters and computational Grids are applied to satisfy computational needs. In addition, these sciences are sometimes characterised by scientific collabora...

Background and novelty In recent decades, substantial progress to mimic structures and complex functions of human skin in the form of skin equivalents has been achieved. Different approaches to generate functional skin models were made possible by the use of improved bioreactor technologies and advanced tissue engineering. Although various forms of skin models are successfully being used in cli...

Background: Mass spectrometry based screening methods have been recently introduced into clinical proteomics. This boosts the development of a new approach for early disease detection: proteomic pattern analysis. Aim: Find, analyze and compare proteomic patterns in groups of patients having different properties such as disease status or epidemio-logical parameters (e.g. sex, age) with a new pip...

In the age of big data, more and more applications need to query and analyse large volumes of continuously updated data in real-time. In response, cloud-scale storage systems can extend their interface that allows fast lookups on the primary key with the ability to retrieve data based on non-primary attributes. However, the need to ingest content rapidly and make it searchable immediately while...