We propose a framework for assessing the hippocampi on stroke patients and studies of small vessel disease, where sclerosis, perivascular spaces and infarcts on this structure are common. It includes hippocampal and cavity segmentations, hippocampal shape modelling, feature characterisation and statistical analyses, all which have been particularly developed for assessing extreme abnormalities ...

This report describes a previously healthy 28 year old patient with a 5 month period of intractable generalised status epilepticus (SE) of unknown aetiology with fatal outcome. Repeated magnetic resonance imaging (MRI) showed no pre-existing abnormality, but did show progressive cortical and hippocampal atrophy and T2 hyperintensity in both hippocampal formations, suggestive of progressive tiss...

Mesial temporal sclerosis (MTS) has been linked to prolonged febrile seizures. The sequence of changes in the temporal lobe/hippocampus following prolonged febrile seizures and status epilepticus is beginning to be elucidated. We obtained repeated magnetic resonance imaging (MRI) volumetric analysis of the hippocampi in a 23-month-old boy after a prolonged focal febrile seizure. Three days afte...

Background Partial epilepsy represents almost 70% of the epileptic syndrome. It is characterized by partial seizures that arise from the restricted area of the cerebral cortex. Temporal lobe epilepsy (TLE) is the most frequent form of cryptogenic partial epilepsies [1]. The mesial temporal sclerosis is the pathologic abnormality most frequently detected in post mortem studies of subjects with T...

The hippocampus is well known to be involved in memory, as well as in perceptual processing. To date, the electrophysiological process by which unilateral hippocampal lesions, such as hippocampal sclerosis (HS), modulate the auditory processing remains unknown. Auditory-evoked magnetic fields (AEFs) are valuable for evaluating auditory functions, because M100, a major component of AEFs, origina...

PURPOSE To determine if ultrahigh-field-strength magnetic resonance (MR) imaging can be used to detect subregional hippocampal alterations. MATERIALS AND METHODS Subjects provided written consent to participate in this prospective institutional review board-approved HIPAA-compliant study. T1- and T2-weighted 7-T brain MR images were acquired in 11 healthy subjects and eight patients with temp...

Commentary The hippocampus is the most frequent target of surgical treatment for epilepsy. Approximately 30% of patients with mesial temporal sclerosis (MTS) on surgical pathology, however, have normal findings on conventional MRI prior to surgery (1). Epilepsy specialists have hoped that ultra-high–field 7-T MRI might improve detection and characterization of MTS for pre-surgical screening (2)...