Some new diazo incorporated coumarin compounds were designed and synthesized to evaluate their anti-HIV activity. Overall, compounds were active against HIV at 100 μM. Additionally, no cytotoxic effect was observed at this concentration. The compound with 4-chlorobenzyl group indicated the best anti-HIV activity (52%). Docking studies using the later crystallographic data available for PFV inte...

A series of 2-benzoxazolinone, diazocoumarin and quinazoline derivatives have been shown to inhibit HIV replication in cell culture. To understand the pharmacophore properties of selected molecules and design new anti-HIV agents, quantitative structure–activity relationship (QSAR) study was developed using a descriptor selection approach based on the stepwise method. Multiple linear regression ...

In an attempt to identify potential new agents that are active against HIV-1, a series of novel pyridopyrimidine-5-carbohydrazide derivatives featuring a substituted benzylidene fragment were designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors. The cytotoxicity profiles of these compounds showed no significant toxicity to human cells and they exhibited anti...

Evaluation of miRNA-122, miRNA-149, miRNA-199a, and miRNA- let7 Expression in HIV, HBV, HIV-HBV Co-infected Patients

Background: In Western and Southwest Asia, literature is not documented on human immunodeficiency virus (HIV) programs in Iran, Iraq and Saudi Arabia. The present study is the first brief review that describes HIV programs in these three neighboring countries.Methods: Data regarding the evidence of HIV programs were gathered through a systematic literature searching. English publications were r...

Background and Objective: Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy. In this study we aimed to determine the prevalence of dyslipidemia and metabolic abnormalities in 2 groups of HIV infected patients receiving highly activ...

Background and Objective: Patients with thalassemia major have an abnormality in hemoglobin synthesis and ineffective hematopoiesis and for this reason with respect to disease severity should receive one or more fresh blood unit every 15-30 days. Since transfusion of blood products has been known as one ...

Background & Aims: Immunodeficiency virus (HIV) may lead to acquired immunodeficiency syndrome (AIDS) in human. Parasites are one of the most important causes of infectious diseases in patients with AIDS. The prevalence of these parasites varies based on the condition of host’s immune system and the stage of disease (HIV/AIDS). To compare the prevalence of opportunistic intestinal parasites a c...