نتایج جستجو برای: hiv fusion inhibitors
تعداد نتایج: 504964 فیلتر نتایج به سال:
CCR5 is the major coreceptor for human immunodeficiency virus (HIV) infection. The murine monoclonal antibody (MAb) 2D7, which recognizes a conformation-dependent epitope in the second extracellular loop of CCR5, is one of the most potent inhibitors of R5 virus cell entry. However, attempts to humanize 2D7 for in vivo human use have been unsuccessful so far. A filamentous phage library expressi...
BACKGROUND Antiretroviral therapy reduces mother-to-child transmission of human immunodeficiency virus (HIV) during pregnancy, delivery, and breastfeeding. However, these agents have been associated with preterm birth, anemia and low birth weight. We aim to evaluate the comparative safety and effectiveness of the use of antiretroviral drugs among HIV-infected women and the effects on their infa...
Recent studies demonstrated that a synthetic fusion peptide of HIV-1 self-associates in phospholipid membranes and inhibits HIV-1 envelope glycoprotein-mediated cell fusion, presumably by interacting with the N-terminal domain of gp41 and forming inactive heteroaggregates [Kliger, Y., Aharoni, A., Rapaport, D., Jones, P., Blumenthal, R. & Shai, Y. (1997) J. Biol. Chem. 272, 13496-13505]. Here, ...
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are widely used in combination therapies against HIV-1. However, emergent and transmitted drug resistance compromise their efficacy the clinical setting. Y181C is selected patients receiving nevirapine, etravirine rilpivirine, together with K103N most prevalent NNRTI-associated mutation HIV-infected patients. Herein, we report on design, ...
BACKGROUND Chemokines bind to specific receptors and mediate leukocyte migration to sites of inflammation. Recently, some chemokine receptors, notably CXCR4 and CCR5, have been shown to be essential fusion factors on target cells for infection by human immunodeficiency virus (HIV); the chemokines bound by these receptors have also been shown to act as potent inhibitors of HIV infection. Here, w...
• Despite successful antiretroviral therapy, patients with human immunodeficiency virus (HIV) could develop multi-class drug resistance (MDR) Data about the prevalence of HIV-MDR are scanty and results unclear A significant decline in over between 1998 2018 was observed Nowadays, still occurs, although at a lower rate Management infected by MDR viruses is critical issue HIV therapy (ART), can (...
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