Angioleiomyoma (ALM; synonyms: angiomyoma, vascular leiomyoma) is an uncommon benign tumor of skin and subcutaneous tissue. Most arise in the extremities (90 %). Head and neck ALMs are uncommon (~10 % of all ALMs) and those arising beneath the sinonasal tract mucosa are very rare (<1 %) with 38 cases reported so far. We herein analyzed 16 cases identified from our routine and consultation files...

A 49-year-old healthy Caucasian woman presented with a sudden change in a lesion on her abdomen. At the time of our consultation, we observed a pigmented papular lesion, 1.5 cm in diameter, surrounded by an incomplete whitish halo with two dark rounded blotches at its top (Figure 1a). The patient had a fair skin phototype and chronic photoaging, characterized by atrophic skin, wrinkling, and di...

BACKGROUND Melanotic Xp11 translocation renal cancer is a rare tumor belonging to the family of microphthalmia-associated transcription factor (MiTF)/transcription factor E (TFE) neoplasms. This tumor family also includes alveolar soft part sarcoma, perivascular epithelioid cell neoplasms, Xp11 translocation renal cell carcinoma, and melanoma. To date, six confirmed melanotic Xp11 translocation...

Hepatic angiomyolipoma (AML) is rare. Based on its wide histomorphological range, several distinctive histological variants have been delineated. However, hepatic AML displaying predominantly or exclusively inflammatory pattern closely mimicking inflammatory pseudotumor (IPT) is exceptionally rare with only 7 cases reported so far. We herein describe a new case of hepatic inflammatory AML in a ...

It is well established that the normal human brain contains populations of neural stem/progenitor cells. Recent studies suggest that they migrate toward a variety of CNS tissue injuries. In an investigation of the potential role of neural stem cells in the pathogenesis of primary CNS lymphomas (NHL-CNS), we observed that neural stem/progenitor cells appeared to accumulate at the border of the t...

Purpose: To develop a genome-based classification scheme for clear-cell sarcoma (CCS), also known as melanoma of soft parts (MSP), which would have implications for diagnosis and treatment. This tumor displays characteristic features of soft tissue sarcoma (STS), including deep soft tissue primary location and a characteristic translocation, t(12; 22)(q13;q12), involving EWS and ATF1 genes. CCS...

BACKGROUND There are various histological prognostic parameters of cutaneous malignant melanoma, including tumor thickness and ulceration. Tumor-infiltrating lymphocytes (TIL) are among these parameters and can be further classified into three categories: 'absent', 'non-brisk' and 'brisk'. Brisk TIL usually indicates better clinical prognosis. Microscopic satellite (Ms) is defined as a nest of ...

Hepatic angiomyolipoma (AML) is rare. Based on its wide histomorphological range, several distinctive histological variants have been delineated. However, hepatic AML displaying predominantly or exclusively inflammatory pattern closely mimicking inflammatory pseudotumor (IPT) is exceptionally rare with only 7 cases reported so far. We herein describe a new case of hepatic inflammatory AML in a ...

Abstract: Primary malignant melanoma of sinonasal tract (PMMST) is a rare but severe form of melanoma. We retrospectively analyzed 17 cases and focused on the histological presentation, the expression of c-Kit, EGFR, cyclin-D1/Bcl-1, PS100 and HMB45 and searched for BRAF, NRAS and KIT mutations that are known to be associated with melanoma subtypes, together with amplifications of KIT, CCND1, C...

Dear Editor, By definition, sarcomas are malignant tumors of tissues, derived from mesoderm and involve the oncogenic transformation of mesenchymal stem cells. The two main types of sarcoma are bone and soft tissue sarcomas. Soft tissue sarcomas generally manifest as deep lesions, but they may affect the skin and subcutaneous tissue.1 They are grouped according to similarities in their clinical...