INTRODUCTION Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter matrix properties and influence disc cell metabolism, contributing to degenerative disc disease and development of discogenic pain. However, little is known about how mechanical strain induces these changes. This study investigated the cellular and molecular changes as well as which inflammatory recepto...

Heteroplasmy, the mixture of mitochondrial genomes (mtDNA), varies among individuals and cells. Heteroplasmy levels alter the penetrance of pathological mtDNA mutations, and the susceptibility to age-related diseases such as Parkinson's disease. Although mitochondrial dysfunction occurs in age-related type 2 diabetes mellitus (T2DM), the involvement of heteroplasmy in diabetes is unclear. We hy...

conclusions pine trees can be used as a worthy bio-indicator for hms pollution monitoring in the ambient air in areas with extensive vegetation of pine trees. results iron had the highest concentration (345.0053 mg/kg) in leaves when compared with other hms. the concentration of zn, cu, pb and cd were 26.1384, 5.5905, 2.9963 and 0.7383 mg/kg, respectively. spatial mapping indicated that industr...

Worldwide competition among manufacturing enterprises has acted as a driving force for the design, development and utilization of manufacturing systems with an increased degree of agility. In these regards, Holonic Manufacturing Systems (HMS) are considered an intelligent systems paradigm to meet requirements for agile manufacturing systems. Despite all advantages of HMS, design and implementat...

Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs. Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square...

The last few years have witnessed an enormous study in the area of integrated hydrological modeling with GIS application. In this research, attempt was made to critically look at the application of HEC-GeoHMS which is an extension of ArcView in HEC-HMS; an HEC package which is a new generation of software being developed for rainfall-runoff simulation. The main role of HEC-GeoHMS is to formulat...

We characterized rabbit antisera to synthetic human calcitonin that specifically recognize the aminoand carboxy-terminal regions of calcitonin (antisera 1-506 and HMS-385, respectively), by both classical (parallelism of dose-response curves) and (owing to the unavailability of a variety of analog fragments of human calcitonin) biochemical plus enzymic alteration of synthetic human calcitonin. ...

A mathematically correct form of the linear storage element’s routing equation is specified requiring only a slight modification of the existing HEC-HMS routine. The new formulation, unlike the current version in use, is unconditionally stable as long as the time step and the storage coefficient values are trivially specified as positive numbers.