The large number of physiological processes regulated by voltage-gated sodium channels (Na v) and their role in many diseases make these channels highly interesting as targets for new drugs. Current research in the pharmaceutical industry mainly focuses on identifying sodium channel blockers that may have therapeutic application in widespread pathological conditions, including epilepsy, cardiac...

BACKGROUND There is some concern that coal seam gas mining may affect health and wellbeing through changes in social determinants such as living and working conditions, local economy and the environment. The onward impact of these conditions on health and wellbeing is often not monitored to the same degree as direct environmental health impacts in the mining context, but merits attention. This ...

Abstract Crystalline silicon becomes photosensitive and absorbing in the sub-bandgap spectral region if hyperdoped, i.e. supersaturated to a level above solubility limit thermal equilibrium, by deep impurities, such as sulfur. Here we apply femtosecond laserpulses crystalline SF 6 atmosphere hyperdoping method. The ultrashort laser pulses cause crystal damage amorphous phases that would decreas...

In open regions of the Ross Sea, role microbial community in turnover organic matter has scarcely been investigated; indeed, very little is known on how distribution and functional diversity respond to environmental conditions hydrographic structures. During austral summer 2017, two pelagic areas Sea [the Drygalski Ice Tongue nearby Terra Nova Bay polynya (A area), continental Shelf Break area ...