Matrix metalloproteinases (MMP) are considered to be critically involved in tumor invasion and the metastasis of various cancers. MMI-166 is a selective inhibitor of matrix metalloproteinase (MMP-2, MMP-9, and MMP-14). The purpose of this study was to evaluate the effects of MMI-166 on both the growth of the implanted tumor and the lymph node metastasis of the mediastinum and prolonging the lif...

The factors formation the efficiency and safety of urinary stone crushing using holmium thulium fiber lasers were selected, substantiated normalized. A multifactorial integral criterion urolithiasis treatment by laser lithotripsy was formed analyzed. Recommendations are given for use stones.

We reported previously that apolipoprotein A-I (apoA-I) is oxidatively modified in the artery wall at tyrosine 166 (Tyr(166)), serving as a preferred site for post-translational modification through nitration. Recent studies, however, question the extent and functional importance of apoA-I Tyr(166) nitration based upon studies of HDL-like particles recovered from atherosclerotic lesions. We dev...

The reliability and lifetime demanded by spacebased applications of 2-micron solid state lasers are beyond the capability of currently available laser diode arrays. This paper provides the status of an ongoing technology advancement effort toward long-lifetime high power laser diode arrays suitable for pumping Thulium and Holmium based solid state lasers.