نتایج جستجو برای: homocysteine thiolactone
تعداد نتایج: 10190 فیلتر نتایج به سال:
A multifunctional coupler with an ethylene carbonate- and a thiolactone ring was synthesized. As proof of principle the coupler was reacted with four low-molecular weight building blocks to form a multifunctional molecule. The reactivity/selectivity of the coupler towards amines, acrylates and acyl halides was evaluated.
PLD-301, a phosphate prodrug of clopidogrel thiolactone discovered by Prelude Pharmaceuticals with the aim to overcome clopidogrel resistance, was evaluated for its in vivo inhibitory effect on ADP-induced platelet aggregation in rats. The potency of PLD-301 was similar to that of prasugrel, but much higher than that of clopidogrel. The results of pharmacokinetic analysis showed that the oral b...
Background: Diabetes mellitus is the most common cause of renal failure, blindness, non- traumatic amputation and neuropathy. Homocysteine, a sulfurated amino acid, has a close correlation with Methionine and Cysteine. The conversion of Methionine to Homocysteine and Cysteine is required coenzymes like vitamin B6, B12 and Folate. The effect of Metformin on serum Homocysteine level by decreasing...
Background and Objective: Increased homocysteine levels resulting from renal failure and physical inactivity in hemodialysis patients can put them at risk for cardiovascular diseases. On the other hand, exercise training may have a favorable effect on homocysteine levels and physical performance in these patients. Therefore, the aim of the present study was to investigate the effect of eight we...
recently multiple studies have shown that elevated homocysteine levels may be associated with ophthalmic vascular disease. to investigate the role of high plasma levels of homocysteine in the patients with retinal vein occlusion, 21 patients with retinal vein occlusion (rvo) and 20 age and sex matched controls without rvo were included in this retrospective case–control study. information regar...
purpose: to evaluate total plasma homocysteine level during the acute phase of central retinal vein occlusion (crvo) compared with a matched healthy group in iranian population, and determine whether hyperhomocysteinemia is also a risk factor for crvo. methods: a study group contains 54 patients presenting with crvo in recent one month, acute phase of the decease, was compared for fasting total...
the distribution of total plasma homocysteine concentrations in relation to the sex and age is described, in a population of shiraz, south west of iran and compared to those reported in other populations. two hundred and one healthy males and 201 healthy females aged >15 y were randomly selected. total plasma homocysteine concentrations were measured using high performance liquid chromatograp...
Background and Objective: In patients with diabetes, elevated homocysteine levels have been reported to be associated with endothelial dysfunction, insulin resistance, dyslipidemia, poor control of disease, nephropathy, macroangiopathy and oxidative stress. Thus, this observational study was performed to determine the plasma homocysteine level and its correlation with clinical, biochemical and ...
background: it is well documented that coronary artery bypass grafting (cabg) with cardiopulmonary bypass (cpb) causes ischemia and oxidative stress of the whole body. to compare the effect of on – pump and off –pump cabg on the induction of the oxidative stress and the metabolism of homocysteine which is involved in the synthesis of glutathione was investigated in the cabg patients during the ...
The synthesis of β-thiolactone and β-lactam analogs of tetrahydrolipstatin is described from a common late-stage β-lactone derivative. These analogs, and a cis-disubstituted β-lactone analog of tetrahydrolipstatin, were screened for activity against porcine pancreatic lipase and for inhibition of cell growth of a panel of four human cancer lines.
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