OBJECTIVES The purpose of the study was to identify predictive factors of tumor response to preoperative chemoradiotherapy for rectal adenocarcinoma. METHODS Ninety-eight patients with nonmetastatic rectal adenocarcinoma received preoperative concurrent chemoradiotherapy and underwent mesorectal excision. After treatment, tumor response according to tumor regression grade were evaluated. The ...

Breast tumor development is regulated in part by cues from the local microenvironment, including interactions with neighboring nontumor cells as well as the ECM. Studies using homogeneous populations of breast cancer cell lines cultured in 3D ECM have shown that increased ECM stiffness stimulates tumor cell invasion. However, at early stages of breast cancer development, malignant cells are sur...

an efficient and green method for the synthesis of pyrano[3,2-c]chromene or pyrano[4,3-b]pyrone derivatives is described by using a three-component condensation process of malononitrile, aldehyde, and 4-hydroxycoumarine or 4-hydroxypyrone in [bmim]bf4-licl as an ionic liquid.

Complex tumor-host interactions can significantly affect the growth dynamics and morphologies of progressing neoplasms. The growth of a confined solid tumor induces mechanical pressure and deformation of the surrounding microenvironment, which in turn influences tumor growth. In this paper, we generalize a recently developed cellular automaton model for invasive tumor growth in heterogeneous mi...

Let $G$ be a locally compact group, $H$ be a compact subgroup of $G$ and $varpi$ be a representation of the homogeneous space $G/H$ on a Hilbert space $mathcal H$. For $psi in L^p(G/H), 1leq p leqinfty$, and an admissible wavelet $zeta$ for $varpi$, we define the localization operator $L_{psi,zeta} $ on $mathcal H$ and we show that it is a bounded operator. Moreover, we prove that the localizat...

The B-cell lymphoma-2 (BCL-2) family of proteins are essential components in the intrinsic apoptosis pathway. While a primary mechanism for removal damaged or unwanted cells, dysregulation this pathway is observed many human cancers. Specifically, BCL-2 overexpression has been associated with pro-survival multiple hematological and solid tumor malignancies. In clinic, inhibitors have demonstrat...

leydig stromal cell tumor is a rare ovarian tumor that belongs to the group of sex-cord stromal tumors. they produce testosterone leading to hyperandrogenism. we present a 41yr old woman with symptoms of virilization and a mass of right adenex via ultra sonography, and a rise of total and free serum testosterone. an ovarian source of androgen was suspected and a surgery performed. a diagnosis o...

we report occurrence of a rare case of giant cell tumor (gct), in a 28-year old woman, arising from anterior arc of right 6 th rib during pregnancy. it progressed rapidly during breast-feeding period, mimicking malignant bone tumor at delayed presentation.