The recently developed field of ligand homology modeling (LHM) that extends the ideas of protein homology modeling to the prediction of ligand binding sites and for use in virtual ligand screening has emerged as a powerful new approach. Unlike traditional docking methodologies, LHM can be applied to low-to-moderate resolution predicted as well as experimental structures with little if any dimin...

A method of quantitative comparison of two classi cations rules applied to protein folding problem is presented. Classi cation of proteins based on sequence homology and based on amino acid composition were compared and analyzed according to this approach. The coe cient of correlation between these classi cation methods and the procedure of estimation of robustness of the coe cient are discussed.