GABAergic drugs can change analgesic effect of morphine. Wide dynamic range (WDR) neurons play an important role in pain transmission and may change behaviors in morphine tolerance. In this study WDR neuron behaviors in morphine tolerant rats and rats treated with GABA agonists, were recorded to elucidate the effect of morphine and GABA agonists on WDR behavioral changes. Rats were divided to 4...

GABAergic drugs can change analgesic effect of morphine. Wide dynamic range (WDR) neurons play an important role in pain transmission and may change behaviors in morphine tolerance. In this study WDR neuron behaviors in morphine tolerant rats and rats treated with GABA agonists, were recorded to elucidate the effect of morphine and GABA agonists on WDR behavioral changes. Rats were divided to 4...

Osteochondritis dissecans (OCD) is a chronic disease of the articular cartilage characterized by focal lesions subchondral bone and overlaying cartilage. Through growing number reports describing high prevalence OCD in some families, subcategory termed familial (FOCD) was established. With development genetic approaches such as genome-wide association studies sequencing, aggrecan (ACAN) has bee...

Targeted treatment with somatostatin analogues (SA) in acromegaly and neuroendocrine neoplasms may have some benefits compared to curative treatments, because these agents decrease excessive hormone secretion exert a tumor-suppressive effect. Monotherapy combination therapy SA is well tolerated bears no risk of debilitating iatrogenic complications. In caused by somatotropin producing pituitary...

BACKGROUND This study evaluated the effect of pituitary desensitization on the early growing follicle population through assessment of serum anti-Mullerian hormone (AMH) concentration. Other markers of ovarian reserve, basal follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol, inhibin-B and three-dimensional ultrasound ovarian parameters were also assessed for comparison. ...