Hot melt extrusion is one of the most popular techniques for manufacturing amorphous solid dispersions (ASDs). Over few decades, it has transitioned from lab scale to commercial with various products in market. The current review aims at summarizing considerations formulation development ASDs using HME. Various types Type I IV are discussed along state drug and polymeric carrier each type. Also...

Infectious disease outbreaks within healthcare facilities can exacerbate patient illness and, in some cases, be fatal. Contaminated surfaces and medical devices act as a reservoir for transmission of pathogens have been linked to the rising incidence healthcare-acquired infections. Antimicrobial reduce microbial contamination emerged crucial component infection control recent years. The aim thi...

the VOCs in the range of 15.0-28.5 ppm (expressed as methane equivalent) were removed. The pungent burnt plastic odor in the test gas was almost completely removed. It requires around 0.058, 0.052, and 0.095 kg of NaOCl solution (12% available Cl ), H O solution (35% H O ), and NaOH 2 2 2 2 2 3 (45%), respectively, for scrubbing 1000 Nm of the exhaust gas and the total chemical costs is around ...

Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targ...

Shrinkage defect in an alloy steel casting for marine engine cylinder cover was estimated by numerical analysis with reference to casting variables such as riser and chiller. Retained melt modulus was employed as a prediction parameter in this study. Shrinkage defects were developed at the final solidification region. This is associated with hot spots, which could be controlled more effectively...

Incorporation of bisphosphonates in the lipid reduces gastric irritation. Only gastric retention with sustained release allows the drug to reach the duodenum and jejunum and improves the availability of bisphosphonates. Risedronate sodium and Gelucire 39/01 floating matrices were prepared using melt solidification. The sustained release floating matrices were evaluated for in vitro and in vivo ...

Phase equilibria modelling incorporating melt reintegration offers a methodology to create hypothetical rock compositions that may have existed prior to melt loss, allowing the potential prograde evolution of rocks to be explored. However, melt reintegration modelling relies on assumptions concerning the volume of melt that was lost and is generally restricted by the absence of direct constrain...

Following the recent success of hot-melt extrusion in the pharmaceutical field, monitoring and control are increasingly applied. In this study, a mathematical model consisting of mass and energy balance partial differential equations is developed and parameters related to material transportation are inferred from experimental data collected from a pilot plant. This data is relative to the outpu...

Lead Zirconate Titanate, PZT, layered into a composite with different materials, produces pre-stressed, curved, devices capable of enhanced displacement. This study focuses on Thunder and Lipca which are built using different combinations of constituent materials. Thunder devices consist of layers of aluminum, PZT, and stainless steel bonded with a hot-melt adhesive. Lipca devices consist of ca...