Androgen induces prostate cell proliferation in the castrated rat. We hypothesized that G1 cyclins, cyclin-dependent kinases (cdk), and cdk inhibitors mediate this cellular response to mitogenic signals. In this study, induction of cyclins D1, D2, D3, E, and cdks 2, 4, and 6 expression was observed at various time points during testosterone replacement in the ventral prostate of castrated rats....

Glycogenin is the self-glycosylating protein primer that initiates glycogen granule formation. To examine the role of this protein during glycogen resynthesis, eight male subjects exercised to exhaustion on a cycle ergometer at 75% Vo2 max followed by five 30-s sprints at maximal capacity to further deplete glycogen stores. During recovery, carbohydrate (75 g/h) was supplied to promote rapid gl...

Corn (Zea mays L.) hybrid selection is one of the most important agricultural management decisions made by farmers. Both genetic yield potential and adaptation to local environment vary widely across corn hybrids, have a direct impact on input costs. This study compared performance hybrids with contrasting comparative relative maturity (CRM, referring their growth cycle), evaluate differences i...

The motor disturbance in Parkinson's disease affects all voluntary movement, including innate rhythmical processes such as gait, breathing, and chewing. While there are good descriptions and pathophysiological hypotheses of the changes in gait less is known about the way masticatory movements are affected. By means of a three-dimensional optoelectronic recording technique the differences were i...

Health technology Two treatment options for patients with anthracycline-pretreated metastatic breast carcinoma were examined. The options were capecitabine (CAP) plus docetaxel (DOC) combination therapy and DOC alone. In the former (CAP+DOC), oral capecitabine (1,250 mg/m2 twice daily was given on days 1 14, followed by a 7-day rest period, with docetaxel (75 mg/m2) administered as a 1-hour int...

Research investigating risk preference has pointed towards motivation and ability as important factors for determining the strength and likelihood of the framing effect. In the current study we explored the influence of individual differences in motivation and ability through circadian rhythm. We predicted that during circadian off-times participants would exhibit stronger framing effects where...

The current scientific literature is replete with investigations providing information on the molecular mechanisms governing the regulation of circadian rhythms by neurons in the suprachiasmatic nucleus (SCN), the master circadian generator. Virtually every function in an organism changes in a highly regular manner during every 24-hour period. These rhythms are believed to be a consequence of t...

Ten day old bush bean plants (Phaseolus vulgaris L. cv Contender) were used to analyze the effects of 3 micromolar Cd on the time courses of expansion growth, dry weight, leaf water relations, stomatal resistance, and abscisic acid (ABA) levels in roots and leaves. Control and Cd-treated plants were grown for 144 hours in nutrient solution. Samples were taken at 24 hour intervals. At the 96 and...

BACKGROUND Considering the crucial role of appropriate preventative strategies in reducing the rate of contrast-induced nephropathy (CIN) occurrence and its related morbidity and mortality, the effect of N-acetylcysteine (NAC), ascorbic acid (AA), and normal saline (NS) was investigated in the patient's undergone coronary angiography. METHODS In this clinical trial, 120 patients scheduled for...

the aim of this investigation was to study macroscopic and microscopic structures of ovaries in barbus grypus of karoon river and their changes during annual maturation cycle. for this purpose, 120 adult  b.grypus with a mean weight of 835.0 to 1012.0 g, were caught from karoon river and transferred alive to the laboratory. after biometrical studies, the weights and morphological appearances of...