OBJECTIVES To examine operative and perinatal aspects of fetal endoscopic tracheal occlusion (FETO) in congenital diaphragmatic hernia (CDH). METHODS This was a multicenter study of singleton pregnancies with CDH treated by FETO. The entry criteria for FETO were severe CDH on the basis of sonographic evidence of intrathoracic herniation of the liver and low lung area to head circumference rat...

1. Describe the incidence of congenital diaphragmatic hernia (CDH). 2. Delineate what percent of all CDHs occur on the left hemithorax and what percent are associated with the presence of other malformations. 3. Describe the mortality rate for prenatally diagnosed CDH and what factors affect the presence of associated malformations and chromosomal defects and are the major determinants of morta...

Cdh16 was initially described as a truncated cadherin expressed in the adult rabbit kidney. We have analyzed the expression pattern of cdh-16 during mouse embryogenesis, and show that cdh-16 transcripts are present in ureter-derived epithelia of the metanephric kidney. In addition, we demonstrate that cdh-16 is also transiently expressed in the epithelia of embryonic sex ducts and the lung of t...

Abstract Background Cellobiose dehydrogenase from Phanerochaete chrysosporium ( Pc CDH) is a key enzyme in lignocellulose depolymerization, biosensors and biofuel cells. For these applications, it should retain important molecular catalytic properties when recombinantly expressed. While homologous expression time-consuming the prokaryote Escherichia coli not suitable for of two-domain flavocyto...

Congenital diaphragmatic hernia (CDH) is a typical neonatal emergency. There is, however, a subset of patients who manifest this congenital anomaly in infancy and early childhood. Late-presenting diaphragmatic hernia is characterized by a variety of gastrointestinal and respiratory symptoms with acute or chronic modes of manifestation. The aim of the study. Analysis of the clinical course, diag...

background: congenital diaphragmatic hernia (cdh) occurs due to a failure in closing pleuroperitoneal membrane thus resulting in an incomplete diaphragm formation1, which allows passage of the abdominal viscera into the thorax.1,3 until 1995, the standard method for treatment of cdh was performed by open surgery through the abdomen or thoracic cavity. minimally invasive approach via thoracoscop...

Despite their low distillate yield, single-slope basin solar stills incorporate a simple and cheap technique to secure potable water in arid rural areas away from fresh resources the power grid. Nevertheless, recovering portion of inevitable thermal losses still will significantly contribute enhancing its daily productivity performance. In this manuscript, latent heat condensation was partially...

Huntington's disease (HD) is caused by an unstable cytosine adenine guanine (CAG) trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin protein. Previously, we identified several up- and down-regulated protein molecules in the striatum of the Hdh(CAG)150 knock-in mice at 16 months of age, a mouse model which is modeling the early human HD stage. Among those molecules, ...

RATIONALE Lung hypoplasia in congenital diaphragmatic hernia (CDH) seems to involve impaired alveolar septation. We hypothesized that disturbed deposition of elastin and expression of fibroblast growth factor 18 (FGF18), an elastogenesis stimulus, occurs in CDH. OBJECTIVES To document FGF18 and elastin in human CDH and ovine surgical and rat nitrofen models and to use models to evaluate the b...

Survivors of severe congenital diaphragmatic hernia (CDH) present significant respiratory morbidity despite lung growth induced by fetal tracheal occlusion (TO). We hypothesized that the underlying mechanisms would involve changes in lung extracellular matrix and dysregulated transforming growth factor (TGF)-β pathway, a key player in lung development and repair. Pulmonary expression of TGF-β s...