BACKGROUND In sublingual immunotherapy, optimal doses are a key factor for therapeutic outcomes. The aim of this study with tablets containing carbamylated monomeric house dust mite allergoids was to determine the most effective and safe dose. METHODS In this double-blind, placebo-controlled dose-finding study, 131 patients with house dust mite-induced allergic rhinoconjunctivitis were random...

Takeo Fujiwara, National Research Institute for Child Health and Development, Tokyo, Japan Kenji Matsumoto, National Research Institute for Child Health and Development, Tokyo, Japan Maiko Osawa, National Research Institute for Child Health and Development, Tokyo, Japan Ikuko Takamatsu, National Research Institute for Child Health and Development, Tokyo, Japan Kenji Tamura, National Institute f...

The purpose of this study was to determine whether the presence of serum specific immunoglobulin E (IgE) antibodies was associated with increased bronchial responsiveness in adults. We studied cross-sectionally a random community sample of 18-73 year old adults, of whom 83% (n = 489) performed bronchial responsiveness testing as well as serum measurements of five specific IgE antibodies. In the...

BACKGROUND Asthma affects an estimated 300 million people worldwide with the condition associated with significant healthcare utilisation costs and a large impact on patient quality of life. The SQ(®) HDM SLIT-tablet (ACARIZAX(®), Hørsholm, Denmark) is a sublingually administered allergy immunotherapy tablet for house dust mite allergic asthma and allergic rhinitis and has recently been license...

Asthma is a chronic life-threatening disease of worldwide importance. Although allergic asthma and related atopic conditions correlate strongly with immune sensitization to house dust mites, it is unclear why antigens from mites provoke such powerful allergic immune responses. We have characterized the protease activity of Der p I, the group I protease allergen of the house dust mite Dermatopha...

Sarsfield, J. K., Gowland, G., Toy, R., and Norman, A. L. E. (1974). Archives of Disease in Childhood, 49, 716. Mite-sensitive asthma of childhood: trial of avoidance measures. A trial of the effects ofmeasures designed to reduce exposure to house-dust mites was performed on 14 children with mite-sensitive asthma. These measures reduced mite infestation of the beds and were associated with clin...

Background Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was to evaluate the safety and efficacy of AIT for house dust mite allergens in patients over 65 years of age with allergic rhinitis (AR) and a documented allergy to house dust mites...

The astigmatid mite Sarcoptes scabiei is the causative agent of scabies, a highly infectious parasitic disease of the skin. Although the mite causes marked hypersensitivity reactions, particularly in crusted (severe) scabies, little is known about the specific scabies mite molecules involved in such immunologic responses. We have identified six genes encoding scabies mite homologues of mu and d...

BACKGROUND In Hawai'i, mortality and morbidity from asthma are significant. In the 80's, there had been no local studies of topography folklore. There had been only one report of seasonal variation in house dust mite (HDM) density in Hawai'i, and this showed no significant variation in O'ahu's Manoa Valley but a definite variation in Waikiki. There were no studies of complete replacement of fur...

Background—Relatively little is known about risk factors for the persistence of asthma and respiratory symptoms from childhood into adolescence, and few studies have included objective measurements to assess outcomes and exposure. Methods—From a large cross sectional study of all 4th grade school children in Munich (mean age 10.2 years), 234 children (5%) with active asthma were identified. Of ...