210 J Neurosurg / Volume 116 / January 2012 INTRACRANIAL hypertension following neurological injury is often associated with poor outcomes.13 Increased ICP reduces CBF and can lead to brain herniation and death. The Brain Trauma Foundation has recommended that therapy to reduce ICP should begin at pressures > 20 mm Hg. Hyperosmolar therapy is a commonly used treatment for intracranial hypertens...

A typical modern high-throughput screening (HTS) operation consists of testing thousands of chemical compounds to select active ones for future detailed examination. The authors describe 3 clustering techniques that can be used to improve the selection of active compounds (i.e., hits). They are designed to identify quality hits in the observed HTS measurements. The considered clustering techniq...

Previous studies on HTS coils can be put into two categories: tape surface coils and thin-film surface coils[1-4]. In this study, we build a whole new Bi2Sr2Ca2Cu2O3 (Bi-2223) superconducting volume coil (length of 8 cm) designed for the mice whole body imaging at Bruker 3T MRI system. The HTS volume coil has 2.3 folds higher S/N than that of the HTS volume coil at 300K for the mice body screen...

A statistical parametric speech synthesis system based on hidden Markov models (HMMs) has grown in popularity over the last few years. This system simultaneouslymodels spectrum, excitation, and duration of speech using context-dependent HMMs and generatesspeechwaveforms from the HMMs themselves. Since December 2002, we have publicly released an open-source software toolkit named HMM-based speec...

High throughput screening (HTS) involves using automated equipment to test a large number of samples against a defined molecular target to identify a reasonable number of active molecules in a timely fashion. Major factors which can influence priorities for the limited resources of the HTS group are projects, productivity, progress and people. The challenge to the HTS group is to provide excell...

α1-Adrenoceptors (ARs; 1A, 1B, and 1D) have been determined to perform different prominent functions in the physiological responses of the sympathetic nervous system. A high-throughput screening assay (HTS) was set up to detect α1-AR subtype-selective agonists by a dual-luciferase reporter assay in HEK293 cells. Using the HTS assay, two novel compounds, CHE3 and CHK3, were discovered as α1-ARs ...

We present the results from sodium magnetic resonance imaging (MRI) experiments using high-temperature superconducting (HTS) receiver coils. Sodium imaging has been shown to have great potential for the assessment of cell integrity but suffers from a substantially lower signal-to-noise ratio (SNR) than that of hydrogen imaging. The use of an HTS receiver coil was found to significantly increase...

Friedman et al examined 156 children 23 to 62 months after births associated with spontaneous labour, labour induced with oxytocin, or labour induced with dinoprostone. The prevalence of neurological or developmental abnormalities not attributable to events after delivery was the same overall in induced and spontaneous labours, but those abnormalities occurring after induction of labour all fol...

High-throughput screening (HTS) is an efficient technology for drug discovery. It allows for screening of more than 100,000 compounds a day per screen and requires effective procedures for quality control. The authors have developed a method for evaluating a background surface of an HTS assay; it can be used to correct raw HTS data. This correction is necessary to take into account systematic e...

Many aspects of the behaviour of high temperature superconducting (HTS) wires are well understood for dc applications. However, models of HTS suitable for use in circuit analysis by power engineers designing HTS applications are not readily available. This paper describes the initial development of suitable models for HTS wire. The V-I characteristics for wires carrying dc transport current can...