The principle of the harmonic analysis method and the its application in the hub runout measurement are introduced in detail in this article, and through the practical measurement data, the geometric meaning of judge the hub quality by the harmonic analysis method is proposed, and the disadvantages of the 8-point coordinate method are analyzed, and the computation method of the Fourier factor i...

Alzheimer's disease (AD) is a progressive neurodegenerative disease involving the alteration of gene expression at the whole genome level. Genome-wide transcriptional profiling of AD has been conducted by many groups on several relevant brain regions. However, identifying the most critical dys-regulated genes has been challenging. In this work, we addressed this issue by deriving critical genes...

Transport networks with hub structure organise the exchange of shipments between many sources and sinks. All sources and sinks are connected to a small number of hubs which serve as transhipment points, so that only few, strongly consolidated transport relations exist. While hubs and detours lead to additional costs, the savings from bundling shipments, i.e. economies of scale, usually outweigh...

A fundamental question is how complex structures are maintained after their initial specification. Stem cells reside in a specialized microenvironment, called niche, which provides essential signals controlling stem cell behavior. We addressed this question by studying the Drosophila male stem cell niche, called the hub. Once specified, the hub cells need to maintain their position and architec...

The niche directs key behaviors of its resident stem cells, and is thus crucial for tissue maintenance, repair and longevity. However, little is known about the genetic pathways that guide niche specification and development. The male germline stem cell niche in Drosophila houses two stem cell populations and is specified within the embryonic gonad, thus making it an excellent model for studyin...

This paper addresses the classical single and multiple allocation hub location problems with fully interconnected hubs, in which balanced round-trip flows on links are considered strategic decision making process. The use of is motivated by need to decrease empty-trip rate vehicles increase full-load vehicles. Mixed-integer programming models presented for versions problems. Numerical experimen...

PURPOSE/OBJECTIVES To determine whether a comprehensive educational program influenced the incidence of hub colonization of central venous catheters (CVCs) and bloodstream infection rates in children with cancer, to identify risk factors related to infection rates, and to determine the impact of an educational program on nurses' knowledge of CVC care for children with cancer. DESIGN Prospecti...

This paper deals with a capacitated hub location problem arising in the design of telecommunications networks. The problem is different from the classical hub location problem in two ways: the cost of using an edge is not linear but stepwise and the capacity of an hub restricts the amount of traffic transiting through the hub rather than the incoming traffic. In this paper both an exact and a h...

The ability of germ cells to carry out a gene regulatory program distinct from the surrounding somatic tissue, and their capacity to specify an entire new organism has made them a focus of many studies that seek to understand how specific regulatory mechanisms, particularly post-transcriptional mechanisms, contribute to cell fate. In zebrafish, germ cells are specified through the inheritance o...

Germ-line stem cells (GSCs) are maintained by the somatic microenvironment, or GSC niche, which ensures that GSCs can both self-renew and produce functional gametes. However, it remains unclear how the proper niche size and location are regulated within the developing gonads. In the Drosophila testis, the hub cells that form the GSC niche are derived from a subset of somatic gonadal precursors ...