a highly sensitive electrochemicalimmunosensor was developed to detect hcg based on immobilization ofhcg-antibody (anti-hcg) onto robust nanocomposite containing gr, chit,1-methyl-3-octyl imidazolium tetra fluoro borate ionic liquid (il)(gr-il-chit). aunps were used to immobilize hcg antibody on the modifiedelectrode. the amine groups of the antibody are covalently attached toaunps/gr-il-chit n...

background and aims: some nanoparticles can be used in immunoassays to increase sensitivity. this study aimed to evaluate a novel nano-immunoassay based on bovine serum albumin nanoparticles (bsa nps). materials and methods: at first, the nanostructure was synthesized, and then applied as a tag in the nano-immunoassay. then the concentration of β-subunit of human chorionic gonadotropin (βhcg) i...

hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma cell line (HTC) lacking endogenous TSHr with the full-length cDNA of the hTSHr. Unlike the wild type, the transfected cells, termed HTC-TSHr c...

Purpose. To improve success of in vitro fertilization (IVF), assisted reproductive technology (ART) experts addressed four questions. What is optimum oocytes number leading to highest live birth rate (LBR)? Are cohort size and embryo quality correlated? Does gonadotropin type affect oocyte yield? Should "freeze-all" policy be adopted in cycles with progesterone >1.5 ng/mL on day of human chorio...

Background: Mid-trimester maternal serum markers have been used for prenatal aneuploidy screening a long time. The aim of the study was to assess mid-term levels β-human chorionic gonadotropin and alpha-fetoproteins placenta-mediated adverse pregnancy outcomes (PMAPOs) in preterm term pregnancies.
 Material methods: A prospective cohort involving nulliparous women with singletons without o...

We present a 9-year-old boy with central precocious puberty and hydrocephalus caused by a human chorionic gonadotropin (beta-hCG) secreting pineal tumor. High levels of beta-hCG in the serum and cerebrospinal fluid were observed in this patient. The patient received radiotherapy and chemotherapy without surgical intervention. Subsequently, significant tumor regression was observed and the serum...

I am disappointed that the recent Q&A article in Clinical Chemistry dealing with assays for human chorionic gonadotropin (hCG) did not mention that all commercial hCG assays in the US are FDA cleared only for the early detection of pregnancy (1 ). The current situation is very unsatisfactory, because these assays, with the knowledge of the manufacturers, are in widespread use for oncology. What...

The uterorelaxant effect of human chorionic gonadotropin (hCG) is regarded as an important mediator in maintenance of uterine quiescence during pregnancy with clinical potential for tocolysis, the mechanisms of which are unknown. The large conductance calcium-activated K(+) channel (BK(Ca)) is ubiquitously encountered in human uterine tissue and plays a significant role in modulating myometrial...

Single particle tracking was used to evaluate lateral motions of individual FLAGtagged human luteinizing hormone (LH) receptors expressed on Chinese hamster ovary (CHO) cells and native LH receptors on both KGN human granulosa-derived tumor cells and M17 human neuroblastoma cells before and after exposure to human chorionic gonadotropin (hCG). Compared to LH receptors on untreated cells, LH rec...

BACKGROUND The effect of progesterone elevation (PE) on the day of human chorionic gonadotropin (hCG) administration on the pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles is a matter of ongoing debate. The replacement of cleavage-stage embryos with blastocyst-stage embryos for transfer was proposed to avoid the possible impairment of PE in fresh ...