the aim of the present research was to study correlation between family functioning components and internalizing and externalizing disorders as well as to determine the contribution of each family functioning component in creating these disorders in 7-11 year old children. this was a descriptive (correlation of prediction type) kind of research. family functioning components were as predictor v...

background: work-related musculoskeletal disorders are the most important factors of absent from work, increased costs and human damages experienced by workers. the aim of this study was to determine the prevalence of work-related musculoskeletal disorders of nurses in al-zahra hospital and the effect of eight-week selected corrective exercises and ergonomic interventions on them. methods: nord...

Intrauterine and postnatal growth disturbances are major clinical features of imprinting disorders, a molecularly defined group congenital syndromes caused by molecular alterations affecting parentally imprinted genes. These genes expressed monoallelically in parent-of-origin manner, they have an impact on human development. In fact, several with exclusive expression from the paternal allele be...

Epigenetic reprogramming of adult human somatic cells to alternative fates, such as the conversion of human skin fibroblasts to induced pluripotency stem cells (iPSC), has enabled the generation of novel cellular models of CNS disorders. Cell reprogramming models appear particularly promising in the context of human neurological disorders of aging such as Alzheimer's disease (AD), Parkinson's d...

Genetic influences on the determination of human fat mass are profound and powerful, a statement that does not conflict with the obvious influence of environmental factors that drive recent changes in the prevalence of obesity. The assertion of the importance of genetic factors has, until recently, largely been based on twin and adoption studies. However, in the last 6 yr, a number of human gen...

3 PREFACE 5 INTRODUCTION 6 ALZHEIMER’S DISEASE: A DISORDER OF PROTEIN MISFOLDING AND SYNAPTIC FAILURE 7 CANCER: A SYSTEMS BIOLOGY DISORDER 7 1. MOLECULAR MECHANISMS OF NEURODEGENERATION 12 CHAPTER AT GLANCE 12 1.1 PHOSPHORYLATION CASCADES AND OXIDATIVE STRESS RESPONSE IN NEURODEGENERATIVE DISEASES ...

Abnormal protein aggregates are commonly observed in affected neurons in many neurodegenerative disorders. We have reported that VCP (valosin-containing protein) co-localizes with protein aggregates in neurons of patients and in cultured cells expressing diseased proteins. However, the significance of such co-localization remains to be elucidated. In the present paper, I discuss the involvement...

Six known or predicted helicases that are mutated in human syndromes are now recognized. These syndromes include xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy, Bloom's syndrome, Werner's syndrome, and alpha-thalassemia mental retardation on the X chromosome. The clinical abnormalities in these syndromes cover a broad spectrum, pointing to different cellular processes of DNA ma...

T he development of new methods for manipulating the mouse genome by transgenic and gene-targeting technologies has dramatically increased our ability to create mouse models for human genetic diseases. These mouse models have greatly facilitated the understanding of the pathogenesis of some human diseases and are beginning to be used in screening of therapeutic agents. In this review, we outlin...

Sufferers of eating disorders often hold false beliefs about their own body size. Such appear to violate norms rationality, being neither grounded by nor responsive appropriate forms evidence. I defend the rationality these beliefs. argue that they are in fact supported evidence, emanating from proprioceptive misperception bodily boundaries. This argument has far-reaching implications for expla...