Targeted drugs therapies that block the molecular pathways involved in the development and progression of gastro-intestinal (GI) cancers have recently gained considerable attention. In addition to agents targeting vascular endothelial growth factor (VEGF), epidermal growth factor receptor, the multi-kinase inhibitor, and regorafenib have also become available for the treatment of metastatic col...

context triple negative breast cancer (tnbc) is a heterogeneous group of diseases that is negative for esterogen receptor (er) progesteron receptor (pr) and human epidermal growth factor receptor 2 (her2). this type of breast cancer is typically high-grade carcinomas, although low-grade tumors occur. the aim of this review is to focus on molecular classification and features, prognostic markers...

Contemporary advancements have had little impact on the treatment of gastric cancer (GC), the world's second highest cause of cancer death. Agents targeting human epidermal growth factor receptor mediated pathways have been a common topic of contemporary cancer research, including monoclonal antibodies (mAbs) and receptor tyrosine kinase inhibitors (TKIs). Trastuzumab is the first target agent ...

Triple negative breast cancer (TNBC): challenges and solutions via the immune cells TNBC is one of the most complicated types of breast cancer to treat. It is generally diagnosed based on the absence of three receptors: estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2) and is thus defined as a triple negative. TNBC is often more aggressive with lower survival rates...

Functional foods have emerged as a new approach to improve human health in term of nutraceutical to prevent people from illness rather than cure patients though medical treatment. In Asian society, particularly in Thailand, the utilizations of functional ingredients have been integrated in every parts of ordinary life. In this study, the tyrosine kinase activity of epidermal growth factor recep...

A cancer stem cell population in malignant brain tumors takes an essential part in brain tumor initiation, growth, and recurrence. Growth factors, such as epidermal growth factor, fibroblast growth factor-2, vascular endothelial growth factor, platelet-derived growth factor, and hepatocyte growth factor, are shown to support the proliferation of neural stem cells and also may play key roles in ...

the role of angiogenic molecules, like vascular endothelial growth factor (vegf) and fibroblast growth factor (fgf) in tumor angiogenesis was well confirmed. photodynamic therapy (pdt) action is, to very high degree, based on tumor vasculature damage. therefore, it seemed to be important to evaluate growth factor receptors after pdt. the extent of receptor expression was studied by immuno-histo...