Serine palmitoyltransferase (SPT) plays the key role on catalysing formation of 3-ketodihydrosphingosine, which is first step de novo biosynthesis sphingolipids. SPT linked to many diseases including fungal infection, making it a potential therapeutic target. Thus, logical docking-based virtual screening method was used screen selective inhibitor against fungi, not human. We myriocin-similarity...

Background: Dorema aucheri (Apiaceae) grows in west and southwest of Iran. Young leaves of this plant are used orally as pickle or for cooking some local foods, as well as for the treatment of parasitic digestive infections and constipation. Objective: The aim of present study was evaluation of cytotoxic potential and total phenols determination of D. aucheri young aerial parts extract and fr...

Conditioned medium from a human myelomonocytic cell line THP-1 promoted the growth of a wide variety of cell types, i.e., human and mouse myeloid cells (HL-60, U937, K562, and M1), mouse T-cells (EL-4), human B cells (Daudi and Raji), mouse mastocytoma cells (IC-2), human melanoma cells (A375-C6), mouse transformed fibroblast cells (L929), human lung fibroblast cells (TIG-1), and mouse bone mar...

objective(s): glioblastoma multiforme (gbm) is one of the most lethal forms of human cancer and temozolomide (tmz) is currently part of the standard treatment for this disease. combination therapy using natural substances can enhance the anti-cancer activity of tmz. the purpose of this study was to evaluate the effect of tmz in combination with thymoquinone (tq) on human gbm cell line (u87mg). ...

background gastric cancer is the second most common cause of cancer death worldwide. lentinan was shown to induce apoptosis in gastric cancer cells and could be used for the treatment of gastric cancer. objectives in this study, we analyzed anticancer effect of lentinan, a fungal β-glucan, on the gastric adenocarcinoma cell line (ags). materials and methods we used the dna ladder and tunnel app...

Background and objectives: Luteolin (3′,4′,5,7-tetrahydroxy flavone) is one of the most common flavones, which is naturally found in several edible plants and traditional medicine. It is known as a non-toxic compound with anti-inflammatory, antinociceptive, anticarcinogenic, antimutagenic, and antiangiogenic properties. Luteolin has antiproliferative activity against different ...

marine streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. the cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (dmehe) from marine derived actinomycete streptomyces sp. vitsjk8 was investigated against mouse embryonic fi...

Curcumin is the natural bio-active component of turmeric (Curcuma longa L.) with known therapeutic properties; nevertheless, its biological applications are limited due to its poor bioavailability. To overcome this limitation, curcumin was conjugated with silica nanoparticles. Curcumin was separated from turmeric by microwave-assisted extraction and silica nanoparticles were developed from rice...

objective: the objective of this study was to investigate inhibition and anti-cancer effects of linoleic acid on the mcf-7 and mda-mb-231 human breast cancer cells. materials and methods: cell lines human breast cancer mcf-7 (gdc055) and mda-mb-231 (htb-26) cell lines were obtained from atcc. mcf-7 estrogen receptor positive human breast cancer cell line and  the estrogen receptor negative huma...