ARI: Acute Respiratory Infections; URTIs: Upper Respiratory Tract Infections; IVs: Influenza Viruses; RSV: Respiratory Syncytial Virus; PIVs: Parainfluenza Viruses; KIPyV: KI Polyomaviruses; WUPyV: WU Polyomaviruses; hMPV: human Metapneumovirus; KEMRI: Kenya Medical Research Institute; GC: Gonococci ; WHO: World Health Organization; CDC; Centers for Disease Control; cDNA: complimentary DNA; RT-...

Abbreviations: HSCT: Hematopoietic Stem Cell Transplantations; ALL: Acute Lymphoblastic Leukemia; URI: Upper Respiratory Infections; Hmpv: Human Metapneumovirus; RSV: Respiratory Syncytial Virus; AML: Acute Myeloblastic Leukemia; LRI: Lower Respiratory Infections; CMV: Cytomegalovirus; Gvhd: Graft Versus Host Disease; BAL: Bronchoalveolar Lavage; PICU: Pediatric Intensive Care Unit; IVIG: Intra...

We analyzed 64 human metapneumovirus strains from eight countries. Phylogenetic analysis identified two groups (A and B, amino acid identity 93%-96%) and four subgroups. Although group A strains predominated, accounting for 69% of all strains, as many B as A strains were found in persons >3 years of age.

Human metapneumovirus (HMPV) was isolated from a 63-year-old multiple myeloma patient who had undergone hematopoietic stem cell transplantation and who presented with lower respiratory tract infection several weeks prior to the diagnosis of lung cancer. The isolate was phylogenetically and biologically characterized and compared to HMPV prototypes and recent pediatric isolates. Remarkably, it b...

Human metapneumovirus (hMPV), a newly discovered paramyxovirus, is associated with acute respiratory-tract illness, primarily in young children, individuals with underlying disease and the elderly. Two genetic lineages of hMPV circulate around the world, and viruses from these two lineages demonstrate antigenic differences. The clinical impact of hMPV warrants the development of vaccines. Recom...

Respiratory syncytial virus (RSV) is a major human pathogen that infects the majority of children by two years of age. The RSV fusion (F) protein is a primary target of human antibodies, and it has several antigenic regions capable of inducing neutralizing antibodies. Antigenic site IV is preserved in both the pre-fusion and post-fusion conformations of RSV F. Antibodies to antigenic site IV ha...

Human metapneumovirus (hMPV) is a relatively recent addition to the multiplicity of viruses causing respiratory illness in infants and children. Although well described in its ability to cause respiratory illness, there is limited data detailing the association of hMPV with neurologic complications. In this report, we describe 2 toddlers with hMPV infection who presented in status epilepticus a...

Human metapneumovirus (HMPV) was recently identified in The Netherlands and was linked to acute respiratory tract illness. In this study, 11 isolates from 10 patients with respiratory disease from Quebec, Canada, were tested by a reverse-transcriptase polymerase chain reaction based on the fusion protein gene. Identified sequences were consistent with HMPV. The patients were 2 months to 87 year...