UNLABELLED Parents have large genetic and environmental influences on offspring's cognition, behavior, and brain. These intergenerational effects are observed in mood disorders, with particularly robust association in depression between mothers and daughters. No studies have thus far examined the neural bases of these intergenerational effects in humans. Corticolimbic circuitry is known to be h...

objective(s): the muller cell is the principal glial cell of the vertebrate retina. the expression of glial fibrillary acidic protein (gfap) in the muller cells was used as a cellular marker for retinal damage. this study was done to evaluate the effect of gestational diabetes on retinal muller cells in rat's offspring. materials and methods: in this experimental study, 12 wistar rat dams ...

The non-targeted effects of human exposure to ionising radiation, including transgenerational instability manifesting in the children of irradiated parents, remains poorly understood. Employing a mouse model, we have analysed whether low-dose acute or low-dose-rate chronic paternal γ-irradiation can destabilise the genomes of their first-generation offspring. Using single-molecule PCR, the freq...

Our work has focused on the carcinogenic effects of in utero arsenic exposure in mice. Our data show that a short period of maternal exposure to inorganic arsenic in the drinking water is an effective, multi-tissue carcinogen in the adult offspring. These studies have been reproduced in three temporally separate studies using two different mouse strains. In these studies pregnant mice were trea...

Abstract. Let T be the extinction moment of a critical branching process Z = (Zn, n ≥ 0) in a random environment specified by iid probability generating functions. We study the asymptotic behavior of the probability of extinction of the process Z at moment n → ∞, and show that if the logarithm of the (random) expectation of the offspring number belongs to the domain of attraction of a non-gauss...

This article is unlikely to help you if your sole focus within the cavy fancy is to make improvements within a well-established, existing breed. Here, tried and tested principles (such as ‘Breed to the best to the best and hope for the best’ and ‘Avoid duplicating faults in the parents and try to ensure that between them they have all the good points you are seeking in the offspring’) probably ...

This work introduces a general mathematical framework for non-stationary fitness functions which enables the exact definition of certain problem properties. The properties’ influence on the severity of the dynamics is analyzed and discussed. Various different classes of dynamic problems are identified based on the properties. Eventually, for an exemplary model search space and a (1, λ)-strategy...

In recent years several authors have obtained limit theorems for Ln, the location of the rightmost particle in a supercritical branching random walk but all of these results have been proved under the assumption that the offspring distribution has (p(O)=.fexp(Ox)dF(x)0. In this paper we investigate what happens when there is a slowly varying function K so that 1-F(x)~x-qK(x) as x...

Genetic variation and inheritance of randomly amplified polymorphic DNA (RAPD) markers in female grass carp (Ctenopharyngodon idella) and male bighead carp (Hypophthalmichthys nobilis) and their F1 offspring hybrid have been studied. For this purpose, genomic DNA was extracted from muscle tissue according to phenol-chloroform method, and six decamer primers were used for amplifying polymorphic ...