background: acyclovir (acv), a synthetic purine nucleoside analogue, is known to be toxic to gonads. objective: the current study evaluated cytotoxicity of acv on histopathological changes in testis tissue and serum testosterone and lipid peroxidation concentrations of male rats. materials and methods: animals were divided into five groups. one group served as control and one group served as co...

Background: Atrazine (ATR) is used as an agriculture herbicide worldwide. It has been shown that ATR adversely affect the reproductive system in rodents. In this study we aimed to evaluate the impact of chronic exposure to Atrazine (ATR) on male testicular tissue, sperm parameters, serum level of total thiol molecules (TTM) and malodialdehyde (MDA) content of testes. Methods: To follow-up th...

The Rho family of GTPases are involved in actin cytoskeleton organization and associated with carcinogenesis and progression of human cancers. We investigated the roles of Rho family GTPases, prototypes RhoA, Rac1, and Cdc42, and the major downstream targets of RhoA, ROCK-I, and ROCK-II in testicular cancer. We quantified protein expression in paired tumor and nontumor samples from surgical spe...

BACKGROUND Germ cell depletion caused by chemical or physical toxicity, disease or genetic predisposition can occur at any age. Although semen cryopreservation is the first reflex for preserving male fertility, this cannot help out prepubertal boys. Yet, these boys do have spermatogonial stem cells (SSCs) that able to produce sperm at the start of puberty, which allows them to safeguard their f...

BACKGROUND Septins are an evolutionary conserved group of GTP-binding and filament-forming proteins that have diverse cellular roles. An increasing body of data implicates the septin family in the pathogenesis of diverse states including cancers, neurodegeneration, and male infertility. OBJECTIVE The objective of the study was to evaluate the expression pattern of Septin14 in testis tissue of...