Background: Due to high differentiation potential and self-renewality, Mesenchymal Stem Cells are now widely considered by researchers in several diseases. FBS is used as a supplement in culture media for proliferation, differentiation, and other culture processes of MSCs, which is associated with transmission risk of a variety of infections as well as immune responses. PRGF derived from platel...

The lack of responsiveness to self and non-self Ags is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this study, we show that CD8(+) T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8(+) regulatory T cell subset. Their suppressive effec...

Background: Natural killer (NK) cells originate from the differentiation of hematopoietic stem (HSCs) in common lymphoid progenitor pathway, and HSCs can be obtained umbilical cord blood (UCB). Comparative studies NK cell between cultured freshly isolated are important development therapy for cancer. This study aimed to compare maturation stages newly HSC samples using interleukin-2 absence fee...

background :cell-based therapies can be used to treat neurological diseases and spinal cord injuries. the aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (bm-mncs) transplantation in patients with spinal cord injuries.   method s: following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to esti...

OBJECTIVE Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. METHODS A total of 144 subjects were divided into 4 groups: normoglycemia (ND; 46 cases), mild gestational hyperglycemia (MGH; 30 cases), gestational diabetes mellitus (GDM; 45 cases) and type-2 diabetes mellitus (DM2; 23 cases). ...

Cord blood banks are institutions designed to store umbilical cord [3] blood (UCB) stem cells [4]. UCB, a source of hematopoietic stem cells [5] (HSCs), has garnered attention from scientific and medical communities since its first successful use in a hematopoietic stem cell transplant (HSCT) in 1988. The umbilical cord [3] is the lifeline by which the growing fetus [6] is nourished by the moth...

Objective(s): Umbilical cord blood is a good source of the mesenchymal stem cells that can be banked, expanded and used in regenerative medicine.  The objective of this study was to test whether amniotic membrane extract, as a rich source of growth factors such as basic-fibroblast growth factor, can promote the proliferation potential of the umbilical cord mesenchymal stem cells. Materials and ...