Among those who have had most experience with the therapeutic use of oxygen in pneumonia, there seems at present to be fairly general agreement as to its value (1) (2) (3) (4) (5). The situation may perhaps be summed up this way: Oxygen in pneumonia is useful in so far as it can relieve or abolish anoxemia. It has no specific effect on the invading microorganism. It does, however, tend to resto...

BACKGROUND Potential benefits or risks of oxygen inhalation for patients with acute myocardial infarction are not fully understood. OBJECTIVE We performed this study to systematically assess the effectiveness and safety of oxygen therapy for patients with acute myocardial infarction. DESIGN A systematic review and meta-analysis. DATA SOURCES We searched randomized controlled trials system...

We have investigated, in volunteers, the effect of inhaling 50% nitrous oxide in oxygen on subsequent oxygenation. Subjects breathed either 50% nitrous oxide in oxygen or 50% nitrogen in oxygen during hyperventilation and normal ventilation. Arterial oxygen saturation and end-expired oxygen concentrations were lower after 50% nitrous oxide in oxygen than after the other mixture with both patter...

Administering liposome-encapsulated drugs by aerosol is a feasible way of targeting drugs to the lungs. Prior to clinical application of aerosolized liposomes as drug carriers, their relative safety must be established. We evaluated the effects of inhaling nondrug-containing liposomes (15 and 150 mg of lipid per milliliter) for 1 h on pulmonary function and on oximetry in ten healthy nonsmoking...

Inhaled nitric oxide (NO) is occasionally used to treat hypoxemia for patients with acute respiratory distress syndrome (ARDS) in the intensive care unit (ICU). However, it is controversial whether or not to maintain inhalation of NO during general anesthesia because of complications, such as nitrogen dioxide (NO(2)) production, methemoglobinemia, and inhibition of platelet aggregation. In this...

Smoke-induced lung injury in rats was assessed in terms of histopathology, gross mortality, neutrophil accumulation and as capillary leak. Administration of hyperbaric oxygen (HBO2), 2.8 atm abs for 45 min, inhibited adhesion of circulating neutrophils subsequent to smoke inhalation. HBO2 reduced pulmonary neutrophil accumulation whether used in a prophylactic manner, 24 h before smoke inhalati...

The phenomenon of diffusion hypoxia is commonly believed to occur unless nitrous oxide-oxygen inhalation sedation is followed by "washout" with 100% oxygen for 5 minutes upon termination of the flow of nitrous oxide. When systematically studied, however, this phenomenon generally appears to be unfounded. The present study evaluated the effect of breathing room air instead of 100% oxygen in heal...

Therapeutic Possibilities of Using an Oxygen-Metabolism Activator (Solcoseryl) by the Systemic and Topical Route in Ophthalmology Many authors are already interested in the therapeutic use of oxygen. Although its usefulness is recognized, technical difficulties have always restricted wider spread of this practice. G. Goldmann L. Liechti [19] S. Schubert [cited in 19] B. Batencke B. Betastoisky ...

Oxygen-15 administered by continuous inhalation and emission computed tomography were used to study regional tissue oxygen utilisation and blood flow in the limbs of 11 patients with venous ulceration and five patients with liposclerosis due to venous insufficiency. The results showed increased blood flow and appreciably reduced fractional oxygen extraction in the diseased tissues. These findin...