OBJECTIVE Hyaluronan (HA) is an important extracellular matrix component and is involved in fluid homeostasis, tissue repair, and response to infections. Previous studies have shown that supplementation of dialysis fluid with high molecular weight HA may have a positive impact on peritoneal solute and fluid transport characteristics. In the present study, we investigated the impact of HA on the...

The glycosaminoglycan (GAG) hyaluronan (HA) is recognized as an important structural component of the extracellular matrix, but it also interacts with cells during embryonic development, wound healing, inflammation, and cancer; i.e., important features in normal and pathological conditions. The specific physicochemical properties of HA enable a unique hydration capacity, and in the last decade ...

Increased synthesis of cervical hyaluronan (HA) from early to late pregnancy has long been proposed to play an essential role in disorganization of the collagen-rich extracellular matrix to allow for maximal compliance and dilation of the cervix during the birth process. Here, we show that HA is not essential for increased cervical distensibility during late pregnancy. Rather, cervicovaginal HA...

Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan composed of repeated disaccharide units of alternating D-glucuronic acid and D-N-acetylglucosamine residues linked via alternating β-1,4 and β-1,3 glycosidic bonds. HA is synthesized in humans by HA synthase (HAS) enzymes 1, 2, and 3, which are encoded by the corresponding HAS genes. Previous in vitro studies have shown char...

3 The abbreviations used are: ROS, reactive oxygen species; VSMC, vascular smooth muscle cells, HA, hyaluronic acid; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; Has2, hyaluronan synthase 2; Hyal3, hyaluronidase 3; LMW-HA, low-molecular-weight HA; HMW-HA, highmolecular-weight HA; DPI, diphenyleneiodonium chloride; DMNQ, 2,3-Dimethoxy-1,4-naphthoquinone; GKT136901 (2-(2-chl...

The study describes an in situ green biosynthesis of zinc oxide nanocomposite using the seaweed Sargassum muticum water extract and hyaluronan biopolymer. The morphology and optical properties of the hyaluronan/zinc oxide (HA/ZnO) nanocomposite were determined by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, transmission electron micros...

An old Indian legend tells a story about six blind men who touched an elephant. The first man who touched his leg said: " it is a pillar. " The second man who touched the tail said: " it is a rope. " The third man who touched the trunk of the elephant said: " it is a thick branch of a tree. " The fourth man who touched the ear said: " It is a big hand fan. " The fifth man who touched the belly ...

Stridh, S. 2013. Regulation of Renal Hyaluronan in Water Handling. Studies in vivo and in vitro. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 951. 76 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8800-0. Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with waterattracting properties. It is the dominating ECM co...

Göransson, V. 2001. Hyaluronan and Renal Fluid Handling. Studies during Normal and Pathological Conditions of Renal Function. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1090. 62 pp. Uppsala. ISBN 91-554-5146-2 The kidney is the major organ responsible for the regulation of the composition and volume of the body fluids, which is ...