PAPER Joanna Aizenberg et al. Microbristle in gels: toward all-polymer reconfigurable hybrid surfaces EMERGING AREA Dmitry G. Shchukin et al. Application of smart organic nanocontainers in feedback active coatings www.softmatter.org We report on the fabrication of biologically-inspired ''smart'' surfaces using hybrid architectures comprising polymer microbristle embedded in a hydrogel layer. Th...

Aim Oral chemotherapy using anticancer drugs would improve the clinical practice and the life quality of patients. The aim of the present study was to develop paclitaxel hybrid nanomicelles for oral administration to treat resistant breast cancer. Methods Evaluations were performed on human breast cancer MCF-7 cells, drug-resistant breast cancer MCF-7/Adr cells, and in MCF-7/Adr-xenografted B...

A new type of fluorescent pH indicator has been developed whereby two dissimilar amino-styryl units are attached to a boron dipyrromethene (Bodipy) dye. The photophysical properties of this hybrid dye, and its simpler counterparts bearing only a single amino-styryl residue, depend on the polarity of the surrounding medium. Of the two terminal amines, DFT (B3LYP/6-31G**) calculations and spectro...

We have previously demonstrated that hybrid adeno-associated viral (AAV) vectors bearing nonhomologous inverted terminal repeats (ITRs) enhance directional intermolecular recombination and the efficiency of dual-AAV vector trans-splicing in cultured cells. Using hybrid-ITR vectors carrying two exons of a lacZ minigene, we demonstrate that this dual-vector approach also mediates higher levels (3...

N-glycosylation plays an important role in the majority of physiological and pathological processes occurring in the immune system. Alteration of the type and abundance of glycans is an element of lymphocyte differentiation; it is also common in the development of immune-mediated inflammatory diseases. The N-glycosylation process is very sensitive to different environmental agents, among them t...

Antigen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2), as well as the expression of specific cell surface receptors for this lymphokine. There are at least two forms of the cellular receptors for IL-2, one with a very high affinity and the other with a lower affinity. We have identified two IL-2 binding peptides, a 55-kd peptide reactive with the anti-Tac m...

Antigen or concanavalin A activation of a murine T-cell hybrid specific for pigeon cytochrome c and restricted to the Ek alpha:Ek beta immune response-associated (Ia) molecule resulted in phosphorylation of a 20-kDa protein that was specifically coprecipitated by a monoclonal antibody binding the T-cell antigen receptor. There was no evidence for phosphorylation of the antigen receptor itself. ...