A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC50 of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively. It exhibited the most potent activity against leukemia Molt 4 cells. Accumulating evidence showed that HQ may act as a potent protein kinase inhibitor in cancer therapy. To full...

the method has been developed and validated for the determination of hydroquinone in liposomal formulation. the samples were dissolved in methanol and evaluated in 293 nm. the validation parameters such as linearity, accuracy, precision, specificity, limit of detection (lod) and limit of quantitation (loq) were determined. the calibration curve was linear in 1-50 µg /ml range of hydroquinone an...

The free H(2)xspa ligands [xspa = pspa, Clpspa, tspa or fspa where p = 3-(phenyl), Clp = 3-(2-chlorophenyl), t = 3-(2-thienyl), f = 3-(2-furyl) and spa = 2-sulfanylpropenoato], their Zn(II) complexes of formula [HQ](2)[Zn(xspa)(2)] (HQ = diisopropylammonium) and the Cd(II) equivalents were prepared and characterized by elemental analysis and by IR, Raman and NMR ((1)H, (13)C) spectroscopy. X-Ra...

Quinine is a promising natural product building block for polymer-based nucleic acid delivery vehicles as its structure enables DNA binding through both intercalation and electrostatic interactions. However, studies exploring the potential of quinine-based polymers applications (transfection) are limited. In this work, we used hydroquinine-functionalized monomer, HQ, with 2-hydroxyethyl acrylat...

Objective: To compare the efficacy and safety of topical silymarin 0.7% with hydroquinone 4% in treatment melasma.
 Place Duration: This Randomized Controlled Trial was conducted at dermatology OPD Akbar Niazi Teaching Hospital, Bara Kahu, Islamabad, a period one year from April 2020 to 2021.
 Patients Methods: Female patients having melasma were included study. The severity assessed ...

Bone marrow is a major target of benzene toxicity, and NAD-(P)H:quinone oxidoreductase (NQO1), an enzyme protective against benzene toxicity, is present in human bone marrow endothelial cells, which form the hematopoietic stem cell vascular niche. In this study, we have employed a transformed human bone marrow endothelial cell (TrHBMEC) line to study the adverse effects induced by the benzene m...

We prove an analog of Janson’s strong hypercontractivity inequality in a class of non-commutative “holomorphic” algebras. Our setting is the q-Gaussian algebras Γq associated to the q-Fock spaces of Bozejko, Kümmerer and Speicher, for q ∈ [−1, 1]. We construct subalgebras Hq ⊂ Γq , a q-Segal-Bargmann transform, and prove Janson’s strong hypercontractivity L(Hq)→ L(Hq) for r an even integer.

Flavin based electron bifurcation (FBEB) is observed in bifurcating transfer flavoproteins (BfEtfs). Electron couples endergonic and exergonic reactions to exploit lower potential reaction step therefore this considered as a third mode of energy conservation mechanism biological systems. We study about the EtfAB system from Rhodoseudomonas palustris (Rpal). This heterodimer containing two flavi...

cell cultures of varthemia persica, peganum harmala and pycnocycla spinosa have been studied to evaluate their abilities to bioconvert exogenous hydroquinone. arbutin is an important substance that has several pharmaceutical applications; therefore, we have established v. persica and p. spinosa cultures which seem to be able to metabolize hydroquinone. callus cultures of v. persica were establi...