This study is aimed at the development of a method to fabricate porous spherical hydroxyapatite (HA)—fluorapatite (FA) granules. The method to produce porous granules is based on liquid immiscibility effect. A suspension of HA–FA powder mixtures in aqueous solution of gelatin and oil as a dispersion media were used. By stirring the mixtures of these immiscible liquids, granules of 50–200 mm dia...

We treated 75 patients with benign bone tumours by curettage and filling the defect with calcium hydroxyapatite (HA). There were 28 women and 47 men with a mean age of 27.7 years (3 to 80). The mean follow-up was for 41.3 months. Postoperative radiological assessment revealed that the implanted HA was well incorporated into the surrounding host bone in all patients. Two patients suffered fractu...

Selective laser sintering (SLS), which is a additive rapid manufacturing technique, it is capable of producing the required product directly and automatically from a 3D computer model representation, have been selected to build implant and scaffold structures using composite materials consisting of a polymer and a bioactive ceramic. Hydroxyapatite (HA), a bioceramic that encourages bone apposit...

The hydroxyapatite (HA) formation on the DNA molecules in SBF was examined. After immersion for four weeks in SBF at 36.5 °C, the HA crystallites of ~1-14 μm in diameter grew on the surface of DNA molecules. Various morphologies were successfully observed through scanning electron microscopy analysis. The Ca/P mol ratio (1.1-1.5) in HA was estimated by energy dispersive X-ray analysis. Original...

A comparative study of in vitro bioactivity of hydroxyapatite (HA) and silicon-doped hydroxyapatite (SiHA) has been carried out by immersion in a cell culture medium with or without fetal bovine serum during 14 days in static and dynamic conditions. A specific bioreactor was developed for the experiments in dynamic conditions. Ceramic surface transformations were characterized by electron micro...

Hydroxyapatite (HA) whisker-reinforced polyetherketoneketone (PEKK) bone ingrowth scaffolds were prepared and characterized. High levels of porosity (75-90%) and HA whisker reinforcement (0-40 vol.%) were attained using a powder processing approach to mix the HA whiskers, PEKK powder and a NaCl porogen, followed by compression molding at 350-375 degrees Celsius and particle leaching to remove t...

Bone is the most implanted tissue after blood. The major solid components of human bone are collagen (a natural polymer, also found in skin and tendons) and a substituted hydroxyapatite (a natural ceramic, also found in teeth). Although these two components when used separately provide a relatively successful mean of augmenting bone growth, the composite of the two natural materials exceeds thi...

Significant research has been devoted to the development of hydroxyapatite (HA) as a coating material for metallic biomaterials used in bioimplants where the biocompatibility is provided by HA while the mechanical properties of the implant are confirmed by the metallic substrates. The in vitro tests of these coatings have conducted by soaking in simulated body fluid (SBF) solutions to evaluate ...

This article presents a histologic evaluation of three hydroxyapatite (HA)-coated root-form implants retrieved from humans after being in function for 3.5 to 11 years. If the coronal portion, where bone loss was observed clinically and radiographically, is excluded, all implants appeared to be well osseointegrated, with intimate contact between the surrounding bone and the coating. There was no...

Prevotella nigrescens ATCC 25261 cells adhere well to protein-blocking hydroxyapatite (HA) which mimics a root surface in the periodontal pocket treated with proteases such as trypsin, proteinase K, chymotrypsin and papain. This study was done to clarify the inhibitory effect of alpha- and beta- serum globulins on the adhesion of P. nigrescens ATCC 25261 cells to trypsin-treated HA. The inhibit...