Haematologica vol. 85(7):July 2000 6. Lip GY. Does atrial fibrillation confer a hypercoagulable state? Lancet 1995; 346:1313-4. 7. Lip GY, Lowe GD, Rumley A, Dunn FG. Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment. Br Heart J 1995; 73:527-33. 8. Kumagai K, Fukunami M, Ohmori M, Kitabatake A, Kamada T, Hoki N. Increased intracardiovascular clott...

Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications such as severe preeclampsia intrauterine growth retardation abruptio placentae and stillbirth has been shown to be associated with thrombophilia. Recurrent miscarriage and has a...

STUDY DESIGN A retrospective database review. OBJECTIVE The aim of this study was to compare complication rates following one to two-level lumbar spine surgery in patients with primary hypercoagulable states and coagulopathies. SUMMARY OF BACKGROUND DATA Both hypercoagulable states and coagulopathies are not uncommon conditions that have the potential to significantly alter perioperative pa...

A relation exists between high altitude exposure and a hypercoagulable state, the nature of which is not entirely clear. This has been mostly reported in mountain climbers. We report a 19-yr-old female, working as a high-altitude chamber instructor, who presented with severe frontal headaches which persisted for a month following routine high altitude chamber training. The patient was in genera...

Mutations in the gene encoding thrombomodulin (TM), a thrombin regulator, are suspected risk factors for venous and arterial thrombotic disease. We have previously described the generation of TM(Pro/Pro) mice carrying a TM gene mutation that disrupts the TM-dependent activation of protein C. Here, it is shown that inbred C57BL/6J TM(Pro/Pro) mice exhibit a hypercoagulable state and an increased...

Alzheimer-type dementia (AD) is a neurodegenerative disorder and the most common form of dementia. Patients typically present with neuro- and systemic inflammation and iron dysregulation, associated with oxidative damage that reflects in hypercoagulability. Hypercoagulability is closely associated with increased fibrinogen and in AD patients fibrinogen has been implicated in the development of ...

Thromboembolic complications have been frequently reported in patients with long-lasting nephrotic syndrome (NS). Although thrombotic complications in the venous system are common in patients with NS, arterial thromboses associated with NS are much less common. However, coronary thromboses are extremely rarely observed. So, NS is a rare cause of acute coronary syndrome (ACS). As such, the incid...

Cortical venous thrombosis (CVT) mostly occurs due to a hypercoagulable state. Infection- related CVT is very rare and medical emergency associated with high mortality rate. It has been described bacterial fungal infections; but only few isolated case reports of tubercular meningitis (TBM) exist. Only six documentations CVT, as complication TBM, exist in the literature. Here, we report young gi...

The clinical management of individuals with hereditary hypercoaguable disorders has evolved from initial broad recommendations of lifelong anticoagulation after first event of venous thromboembolism to a more intricate individualized risk-benefit analysis as studies have begun to delineate the complexity of interactions of acquired and hereditary factors which determine the predilection to thro...