ANNA M. LOMBARDI,1 ROBERTO FABRIS,1 FLAVIA BASSETTO,1 ROBERTO SERRA,1 ARMELLE LETURQUE,2 GIOVANNI FEDERSPIL,1 JEAN GIRARD,2 AND ROBERTO VETTOR1 1Endocrine Metabolic Laboratory, Department of Medical and Surgical Sciences, University of Padova, 35100 Padova, Italy; and 2Centre de Recherche sur l’Endocrinologie et le Développement, Centre National de la Recherche Scientifique, 92190 Meudon-Bellev...

BACKGROUND The cecal ligation and puncture (CLP) model, a gold standard in sepsis research, is associated with an important variability in mortality. While the number of punctures and needle size is well described in CLP animal studies, the length of cecal ligation is often not. The relationship between cecal ligation and survival in mice is briefly reported in the literature; therefore, we dev...

Background: As stavudine remains an important and widely prescribed drug in resource-limited settings, the effect of a reduced dose of stavudine (from 40 mg to 30 mg) on outcomes of highly active antiretroviral therapy (HAART) remains an important public health question. Methods: We analyzed prospectively collected data from the Themba Lethu Clinic in Johannesburg, South Africa. We assessed the...

OBJECTIVE The physical examination of peripheral perfusion based on touching the skin or measuring capillary refill time has been related to the prognosis of patients with circulatory shock. It is unclear, however, whether monitoring peripheral perfusion after initial resuscitation still provides information on morbidity in critically ill patients. Therefore, we investigated whether subjective ...

"Diseases are conceptually all alike, although each syndrome is cumbersome in its own way". This paraphrase of the beginning sentence of Tolstoi's Anna Kareninna emphasizes the complexity of dealing with a kaleidoscopic mix of signs and symptoms and their interplay. Syndromes are a mainstay of critical care medicine; no other medical specialty deals more regularly with syndromes than intensive ...