The patient was a 7-year-old child of gypsy origin, with no relevant personal history, who presented with progressively developing, asymptomatic, hyperpigmented lesions, first observed 11 months earlier. The lesions had started to appear on the upper part of the trunk and had shown a centrifugal progression, becoming generalized over the course of a few months. No triggering event was identifie...

A 32 years old female presented with a single asymptomatic lesion on right thigh since 5 years. On examination, a single ill defined, irregular hyperpigmented plaque was present on medial aspect of right thigh. The plaque was firm in consistency and was non-tender. No scaling was evident. Clinically a differential diagnosis of Hansen’s disease, lupus vulgaris and deep fungal infection were made...

The patient was a 7-year-old child of gypsy origin, with no relevant personal history, who presented with progressively developing, asymptomatic, hyperpigmented lesions, first observed 11 months earlier. The lesions had started to appear on the upper part of the trunk and had shown a centrifugal progression, becoming generalized over the course of a few months. No triggering event was identifie...

Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare condition, in which the skin of the nipple and/or areola becomes diffusely thickened, hyperpigmented, and covered with filiform or papular warty excrescences. Although it affects both men and woman, approximately 80% of cases ocur in women. Pathogenic mechanisms have been proposed but mainly unsubstantiated. Moreover, specific trea...

background: cutaneous manifestations are commonly observed in the neonatal period. it is important to differentiate physiologic skin lesions from pathologic ones to avoid parents’ concerns. regarding this, the current study aimed to investigate the frequency and localization of salmon patch (sp) and mongolian spot (ms) in iranian newborns to assess the potential relationship between the neonata...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

Demodex mites may induce inflammatory cutaneous reactions such as papulopustular rosacea and demodex folliculitis; both may lead to post inflammatory pigmentation. A 59-year-old man presented with an asymptomatic, hyperpigmented plaque on his face. Histological and clinical findings displayed Riehl-like facial pigmentation. Multiple demodex mites at the follicular infundibulum in the biopsy mat...

Incontinentia Pigmenti, also known as Bloch-Sulzberger syndrome, is a rare X-linked dominant disorder considered to be lethal in males. The syndrome usually presents at birth or shortly thereafter and the skin rash evolves in the classic four stages of vesicular, verrucous, hyperpigmented, and hypopigmented lesions following a blaschko linear distribution. Here we present an unusual case of Inc...

Dermatosis papulosa nigra (DPN) is a benign skin condition characterized by multiple, small, hyperpigmented macules and papules found on the malar areas of the face, neck, and trunk. It is almost always seen in the black population. Prevalence of DPN in the black population has been reported to be between 10% and 35%, with many patients noting a family history of the lesions and the number of l...

DUH: dyschromatosis universalis hereditaria IPL: intense pulsed light INTRODUCTION Characterized by hyperpigmented and hypopigmented macules forming a reticulate pattern, dyschromatosis universalis hereditaria (DUH) was first described by Toyamo in Japan. Subsequent cases have been reported from other areas including Europe, China, Saudi Arabia, Tunisia, India, and Nigeria. A variable autosomal...