Hypertrophic obstructive cardiomyopathy (HOCM) is a common genetic cardiovascular disease that can lead to significant morbidity and mortality. Patients with HOCM often present with symptoms of dyspnea, angina, syncope, and heart failure, which can be refractory to medical therapy. An alternative approach is alcohol septal ablation (ASA). This minimally invasive treatment has gradually gained a...

Hypertrophic obstructive cardiomyopathy is a disorder of ventricular muscle characterized by asymmetrical hypertrophy and unusually rapid ventricular ejection of a normal stroke volume (Goodwin et al., 1960; Braunwald et al., 1964). The presence of a systolic gradient between the left ventricle and the aorta has been taken as evidence of obstruction of the ventricular outflow tract, but recent ...

Mailing Address: Jorge Humberto Guardado • Serviço de Cardiologia – Hospital Garcia de Orta 2800 Almada – Portugal E-mail: [email protected] Manuscript received May 28, 2006; revised manuscript received June 12, 2006; accepted June12, 2006.

Twenty-two patients with hypertrophic obstructive cardiomyopathy were treated with the calcium inhibitor, verapamil, which was administered in a mean oral dose of 480 mg per day. After an average of 15 months of treatment (4 to 24 months), the QRS amplitude in the electrocardiogram was significantly reduced from 4.2 to 3.8 mV. Heart volume calculated from chest x-ray films in the supine positio...

Rev Esp Cardiol 2003;56(12):1231 1231 A 62-year-old patient had symptomatic hypertrophic obstructive cardiomyopathy diagnosed six years ago. Despite medical treatment, dyspnea progressed during follow-up and a two-chamber pacemaker had been implanted one year previously. The reason for the current hospitalization was worsening symptoms (functional class III). The dynamic left ventricular outflo...

Fro Su St. an Yo rel Ma Mitral valve abnormalities were not part of modern pathological and clinical descriptions of hypertrophic cardiomyopathy in the 1950s, which focused on left ventricular (LV) hypertrophy and myocyte fiber disarray. Although systolic anterior motion (SAM) of the mitral valve was discovered as the cause of LV outflow tract obstruction in the M-mode echocardiography era, in ...

Septal myectomy effectively relieves left ventricular outflow tract obstruction (LVOTO) and cardiac symptoms in both adults and children with obstructive hypertrophic cardiomyopathy (HCM). Abnormal attachments of the papillary muscles and chordae and other cardiac lesions can be repaired at the same time. Early mortality for isolated septal myectomy in both children and adults is low (0% to 2.5...

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An 84-year-old woman diagnosed with hypertrophic obstructive cardiomyopathy (HOCM) was referred to our hospital due to chest pain associated with an increased level of troponin T. Following the administration of cibenzoline, the left ventricular outflow pressure gradient (LVPG) completely disappeared. Left ventricular pressure pullback tracing subsequently demonstrated the "reappearance" of the...