Wound reparative process after surgery, burns, injuries, and infl ammatory processes results in a spectrum of scar formation ranging from nearly scarless healing to excessive fi brosis or atrophy. S carring is considered a major medical problem that leads to aesthetic and functional sequelae. Scar tissue is clinically distinguished from normal skin by an aberrant color, rough surface texture, i...

Introduction: An abnormal frenulum can cause aesthetic and functional problems such as a midline diastema, localized gingival recession, loss of sulcus depth and ankyloglossia. This may lead to problems with speech articulation and swallowing. The aim of this article was to highlight the use of a novel surgical technique used for the treatment of hypertrophic frenula known as Z-Frenuloplasty. M...

BACKGROUND Topical silicone gel sheeting has been used for more than 20 years to help reduce the size of hypertrophic scars and keloids. Its clinical efficacy and safety is well established. OBJECTIVE To determine whether topical silicone gel sheeting can be used to prevent hypertrophic scars and keloids from forming following dermatologic skin surgery. METHODS Patients undergoing skin surg...

OBJECTIVE To evaluate human corneas after laser-assisted in situ keratomileusis at different postoperative intervals. METHODS Thirty-eight postmortem corneas from 20 patients with postoperative intervals from 2 months to 6.5 years after laser-assisted in situ keratomileusis surgery were collected from eye banks. The corneas were trisected and processed for conventional histologic analysis, tr...

Reparative process of second and third degree burns usually results in hypertrophic scar formation that can be treated by pressure. Although this method is efficient, its mechanisms of action are not known. In this work, we have studied the histological organization of hypertrophic scars submitted to pressure. Skin biopsies were performed 2 to 7 months after the onset of treatment in two adjace...

Introduction : Abnormal scar recurrence can occur and often be greater than pre-excision because the rate is giving a high percentage. Data about keloid hypertrophic are rarely found in Indonesia. Therefore, it necessary to conduct research related abnormal scar, aims determine incidence of support future by valuable data. Method A retrospective descriptive study that evaluated post-excision pa...

Objectives Therapeutic effect of many selectable methods applied in clinical practice for treating hypertrophic scar (HS) is not still so satisfactory. Meanwhile, a few medicines may lead to several undesirable complications. The traditional Chinese medicine, Rg3, has been reported for multiple antitumor effects previously. We have conducted series of animal experiments and confirmed the inhibi...

BACKGROUND Our complete understanding of hypertrophic scarring is still deficient, as portrayed by the poor clinical outcomes when treating them. To address the need for alternative treatment strategies, we assess the swine animal burn model as an initial approach for immature scar evaluation and therapeutic application. METHODS Thermal contact burns were created on the dorsum of 3 domestic s...

Astrogliosis following spinal cord injury (SCI) involves an early hypertrophic response that serves to repair damaged blood-brain barrier and a subsequent hyperplastic response that results in a dense scar that impedes axon regeneration. The mechanisms regulating these two phases of astrogliosis are beginning to be elucidated. In this study, we found that microRNA-21 (miR-21) increases in a tim...

Hypertrophic scars (HS) area fibroproliferative disorder of the skin, which causes aesthetic and functional impairment. However, the molecular pathogenesis of this disease remains largely unknown and currently no efficient treatment exists. MicroRNAs (miRNAs) are involved in a variety of pathophysiological processes, however the role of miRNAs in HS development remains unclear. To investigate t...