Aims: To investigate seasonal variation in anti-diabetic and hypolipidemic activities of Momordica charantia fruits harvested at different seasons of the year, namely spring, summer, autumn and winter. Methodology: Air-dried and pulverized fruit samples were extracted by soaking in 70% methanol for 72h. The filtrate was concentrated using rotary evaporator. The yields of spring (MME), summer (J...

Maslinic acid is a pentacyclic triterpenoid acid. Recent research has shown that it various biological activities such as anti-tumor, hypoglycaemic and hypolipidemic. Among them, the hypolipidemic effect prominent this study aims to further explore its mechanism of action in treatment hyperlipidemia. The chemical structure maslinic was obtained from PubChem. Based on structure, bioavailability ...

BACKGROUND: Despite the available range of lipid-lowering drugs, mainly synthetic origin, problem atherosclerosis therapy and its manifestations remain unresolved. Bioinformatics methods, in particular molecular docking, are considered as a promising direction terms developing effective original drugs. Today, source natural agents, it is advisable to consider terpenoids, namely sesquiterpene la...

In traditional Chinese medicine (TCM), purgation is indicated when a person suffers an illness due to the accumulation of evil internal heat. Obese individuals with a large belly, red face, thick and yellow tongue fur, constipation, and avoidance of heat are thought accumulates of evil internal heat, and they are also treated with purgatives such as Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang ...

BACKGROUND Studies demonstrated that visit-to-visit variability in low-density lipoprotein cholesterol (LDLC) is an independent predictor of cardiovascular events in subjects with coronary artery disease. Whether visit-to-visit variability in LDLC levels affects subclinical atherosclerosis is unknown. This study sought to evaluate the role of visit-to-visit variability in LDLC levels on subclin...

Cardiovascular problems have been haunting human populations for a long time with no specific cure. It is believed that a shift in the eating, and physical habits might have paved the way for the alarming increase in cardiovascular diseases. Increase in the lipid level has been pinpointed as an important risk factor. Hence epidemiological and clinical studies were undertaken throughout the worl...

Nutraceuticals are food components or active ingredients present in foods and used in therapy. This article analyzes the characteristics of the molecules with a lipid-lowering effect. The different nutraceuticals may have different mechanisms of action: inhibition of cholesterol synthesis primarily through action on the enzyme HMG-CoA reductase (policosanol, polyphenols, garlic and, above all, ...

71 Received December 19, 2014; revised and accepted April 24, 2015. Published online May 16, 2015; doi: 10.1620/tjem.236.71. Correspondence: Xiangdong Gao, School of Life Science and Technology, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, Jiangsu, P.R.China. e-mail: [email protected] Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers i...